Should antioxidant status be considered in interventional trials with antioxidants?

被引：32

作者：

Violi, F ^{[1
]}

Loffredo, L ^{[1
]}

Musella, L ^{[1
]}

Marcoccia, A ^{[1
]}

机构：

[1] Univ Roma La Sapienza, Div Clin Med 4, I-00161 Rome, Italy

来源：

HEART | 2004年 / 90卷 / 06期

关键词：

D O I：

10.1136/hrt.2003.026930

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The last decade has seen many trials with antioxidants in patients with cardiovascular disease, with equivocal results. One possible explanation for the disappointing findings is the lack of identification criteria of patients who are potential candidates for antioxidant treatment. Several studies have been carried out in patients at risk of cardiovascular disease, indicating that enhanced oxidative stress is associated with the presence of diabetes, hypercholesterolaemia, hypertension, and smoking. This review analyses the data reported so far to determine whether they clearly support the premise that patients at risk of cardiovascular events may be candidates for antioxidant treatment.

引用

页码：598 / 602

页数：5

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