Distinct transcriptional outputs associated with mono- and dimethylated histone H3 arginine 2

被引：39

作者：

Kirmizis, Antonis ^{[1
,2
]}

Santos-Rosa, Helena ^{[1
,2
]}

Penkett, Christopher J. ^{[3
]}

Singer, Michael A. ^{[4
]}

Green, Roland D. ^{[4
]}

Kouzarides, Tony ^{[1
,2
]}

机构：

[1] Gurdon Inst, Cambridge CB2 1QN, England

[2] Dept Pathol, Cambridge CB2 1QN, England

[3] EMBL European Bioinformat Inst, Cambridge CB10 1SD, England

[4] NimbleGen Syst Inc, Madison, WI 53711 USA

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2009年 / 16卷 / 04期

关键词：

METHYLATION; H4;

D O I：

10.1038/nsmb.1569

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Dimethylation of histone H3 Arg2 (H3R2me2) maintains transcriptional silencing by inhibiting Set1 mediated trimethylation of H3K4. Here we demonstrate that Arg2 is also monomethylated (H3R2me1) in yeast but that its functional characteristics are distinct from H3R2me2: (i) H3R2me1 does not inhibit histone H3 Lys4 (H3K4) methylation; (ii) it is present throughout the coding region of genes; and (iii) it correlates with active transcription. Collectively, these results indicate that different H3R2 methylation states have defined roles in gene expression.

引用

页码：449 / 451

页数：3

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