B lymphocyte depletion therapy with rituximab in rheumatoid arthritis

被引：71

作者：

Edwards, JCW ^{[1
]}

Leandro, MJ ^{[1
]}

机构：

[1] UCL, Ctr Rheumatol, London W1T 4NJ, England

来源：

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA | 2004年 / 30卷 / 02期

关键词：

D O I：

10.1016/j.rdc.2004.01.006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

B lymphocyte depletion therapy in rheumatoid arthritis can provide major clinical benefits. Widespread use in the future will depend on continued evidence of safety, particularly in the context of long-term use. Rituximab is a highly effective agent, but it may be best used in combination with other agents. Substantial improvement following a single course of therapy has been found to last up to 42 months, and it is reasonable to hope that further development of strategies targeting B cells will extend this toward the original aim of truly long-term remission.

引用

页码：393 / +

页数：12

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