Solid-phase synthesis of FKBP12 inhibitors:: N-sulfonyl and N-carbamoylprolyl/pipecolyl amides

被引：11

作者：

Wei, L ^{[1
]}

Wu, YQ ^{[1
]}

Wilkinson, DE ^{[1
]}

Chen, Y ^{[1
]}

Soni, R ^{[1
]}

Scott, C ^{[1
]}

Ross, DT ^{[1
]}

Guo, H ^{[1
]}

Howorth, P ^{[1
]}

Valentine, H ^{[1
]}

Liang, S ^{[1
]}

Spicer, D ^{[1
]}

Fuller, M ^{[1
]}

Steiner, J ^{[1
]}

Hamilton, GS ^{[1
]}

机构：

[1] Guilford Pharmaceut Inc, Res Dept, Baltimore, MD 21224 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 10期

关键词：

D O I：

10.1016/S0960-894X(02)00146-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In parallel with our work on solution-phase parallel synthesis of ligands for the rotamase enzyme FKBP12, we herein report a methodology for the solid-phase synthesis of two classes of inhibitor, N-sulfonyl and N-carbamoylprolyl and pipecolyl amides along with their in vitro/in vivo biological results. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1429 / 1433

页数：5

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