The modulation of skeletal muscle contraction by FMRFamide-related peptides of the locust

被引:22
作者
Lange, AB [1 ]
Cheung, IL [1 ]
机构
[1] Univ Toronto, Erindale Coll, Dept Biol, Mississauga, ON L5L 1C6, Canada
基金
加拿大自然科学与工程研究理事会;
关键词
SchistoFLRFamide; FMRFamide; locust; Bztc; excitatory junction potential; FaRP;
D O I
10.1016/S0196-9781(99)00150-3
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The external ventral protractor muscle of the VIIth abdominal segment, M234, is a skeletal muscle that possesses receptors that recognize a range of FMRFamide-related peptides and application of these peptides results in an increase in the amplitude of neurally evoked contractions with little or no effect on basal tonus. FLRFamide itself has the same biologic activity as the extended peptides, whereas truncation to LRFamide or RFamide results in a peptide with no biologic activity. The receptors recognizing these extended FLRFamides, which include SchistoFLRFamide, seem to be different from the SchistoFLRFamide receptors found on locust oviduct visceral muscle. SchistoFLRFamide and the non-peptide mimetic, benzethonium chloride (Bztc), increase the frequency and amplitude of miniature endplate potentials, increase the amplitude of neurally evoked excitatory junction potentials, and result in a hyperpolarisation of resting membrane potential. Bztc, however, also abolishes the active membrane response that may explain its ability to decrease neurally evoked contractions (C) 1999 Elsevier Science Inc. All rights reserved.
引用
收藏
页码:1411 / 1418
页数:8
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