Synchronization of Midbrain Dopaminergic Neurons Is Enhanced by Rewarding Events

被引：59

作者：

Joshua, Mati ^{[1
,2
]}

Adler, Avital ^{[1
,2
]}

Prut, Yifat ^{[1
,2
]}

Vaadia, Eilon ^{[1
,2
]}

Wickens, Jeffery R. ^{[4
]}

Bergman, Hagai ^{[1
,2
,3
]}

机构：

[1] Hebrew Univ Jerusalem, Hadassah Med Sch, Dept Physiol, IL-91120 Jerusalem, Israel

[2] Hebrew Univ Jerusalem, Interdisciplinary Ctr Neural Computat, IL-91904 Jerusalem, Israel

[3] Hebrew Univ Jerusalem, Eric Roland Ctr Neurodegenerat Dis, IL-91904 Jerusalem, Israel

[4] Okinawa Inst Sci & Technol, Okinawa 9042234, Japan

来源：

NEURON | 2009年 / 62卷 / 05期

关键词：

TONICALLY ACTIVE NEURONS; STRIATAL CHOLINERGIC INTERNEURONS; SPINY PROJECTION NEURONS; BASAL GANGLIA; ACTION-POTENTIALS; EXTRACELLULAR ELECTROPHYSIOLOGY; PARKINSONIAN PRIMATES; PREDICTION ERROR; AVERSIVE EVENTS; SPIKE TRAINS;

D O I：

10.1016/j.neuron.2009.04.026

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

The basal ganglia network is divided into two functionally related subsystems: the neuromodulators and the main axis. It is assumed that neuromodulators adjust cortico-striatal coupling. This adjustment might depend on the response properties and temporal interactions between neuromodulators. We studied functional interactions between simultaneously recorded pairs of neurons in the basal ganglia while monkeys performed a classical conditioning task that included rewarding, neutral, and aversive events. Neurons that belong to a single neuromodulator group exhibited similar average responses, whereas main axis neurons responded in a highly diverse manner. Dopaminergic neuromodulators transiently increased trial-to-trial (noise) correlation following rewarding but not aversive events, whereas cholinergic neurons of the striatum decreased their trial-to-trial correlation. These changes in functional connectivity occurred at different epochs of the trial. Thus, the coding scheme of neuromodulators (but not main axis neurons) can be viewed as a single-dimensional code that is further enriched by dynamic neuronal interactions.

引用

页码：695 / 704

页数：10

共 70 条

[1]

Abeles M, 1982, Local cortical circuits: An electrophysiological study, DOI DOI 10.1007/978-3-642-81708-3

[2]

DYNAMICS OF NEURONAL FIRING CORRELATION - MODULATION OF EFFECTIVE CONNECTIVITY [J].

AERTSEN, AMHJ ;

GERSTEIN, GL ;

HABIB, MK ;

PALM, G .

JOURNAL OF NEUROPHYSIOLOGY, 1989, 61 (05) :900-917

[3]

PARALLEL ORGANIZATION OF FUNCTIONALLY SEGREGATED CIRCUITS LINKING BASAL GANGLIA AND CORTEX [J].

ALEXANDER, GE ;

DELONG, MR ;

STRICK, PL .

ANNUAL REVIEW OF NEUROSCIENCE, 1986, 9 :357-381

[4]

AOSAKI T, 1994, J NEUROSCI, V14, P3969

[5]

Space, time and dopamine [J].

Arbuthnott, Gordon W. ;

Wickens, Jeff .

TRENDS IN NEUROSCIENCES, 2007, 30 (02) :62-69

[6]

Arkadir D, 2002, ADV BEHAV BIOL, V52, P181

[7]

Neural correlations, population coding and computation [J].

Averbeck, BB ;

Latham, PE ;

Pouget, A .

NATURE REVIEWS NEUROSCIENCE, 2006, 7 (05) :358-366

[8]

Coding and transmission of information by neural ensembles [J].

Averbeck, BB ;

Lee, D .

TRENDS IN NEUROSCIENCES, 2004, 27 (04) :225-230

[9]

Multiple single unit recording in the cortex of monkeys using independently moveable microelectrodes [J].

Baker, SN ;

Philbin, N ;

Spinks, R ;

Pinches, EM ;

Wolpert, DM ;

MacManus, DG ;

Pauluis, Q ;

Lemon, RN .

JOURNAL OF NEUROSCIENCE METHODS, 1999, 94 (01) :5-17

[10]

Synchronization in monkey motor cortex during a precision grip task. I. Task-dependent modulation in single-unit synchrony [J].

Baker, SN ;

Spinks, R ;

Jackson, A ;

Lemon, RN .

JOURNAL OF NEUROPHYSIOLOGY, 2001, 85 (02) :869-885

← 1 2 3 4 5 6 7 →