Expression analysis of BCL2L12, a new member of apoptosis-related genes, in colon cancer

被引：34

作者：

Mathioudaki, K

Scorilas, A

Papadokostopoulou, A

Xynopoulos, D

Arnogianaki, N

Agnanti, N

Talieri, M ^{[1
]}

机构：

[1] St Savas Hosp, G Papanicolaou Res Ctr Oncol, GR-11522 Athens, Greece

[2] Univ Athens, Fac Biol, Dept Biochem & Mol Biol, GR-15711 Athens, Greece

[3] St Savas Hosp, Dept Gastroenterol, GR-11522 Athens, Greece

[4] St Savas Hosp, Dept Pathol, GR-11522 Athens, Greece

[5] Univ Ioannina, Sch Med, Dept Pathol, GR-45110 Ioannina, Greece

来源：

BIOLOGICAL CHEMISTRY | 2004年 / 385卷 / 09期

关键词：

apoptosis; BCL2L12; colon cancer;

D O I：

10.1515/BC.2004.101

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Apoptosis is an active process regulated by a variety of genes. Recently, the molecular cloning, physical mapping and expression analysis of a novel gene of the Bcl-2 family, BCL2L12, was reported. Expression analysis of the BCL2L12 gene in breast cancer confirmed an association of BCL2L12 with favorable prognosis of patients. In the present study, the expression of the BCL2L12 gene was analyzed in colon cancer by RTPCR. Two transcripts, BCL2L12 and BCL2L12-A, were overexpressed in the cancer tissues as compared to their paired normal mucosa. An association was found between BCL2L12-A transcript expression and nodal status, as well as Dukes stage. The BCL2L12-A transcript appears to be of importance for colon cancer since its expression is associated with disease progression.

引用

页码：779 / 783

页数：5

共 20 条

[1] The Bcl-2 protein family: Arbiters of cell survival [J].