Regulation of lipid peroxidation and ferroptosis in diverse species

被引：470

作者：

Conrad, Marcus ^{[1
]}

Kagan, Valerian E. ^{[2
,3
,4
,5
,6
]}

Bayir, Hulya ^{[2
,7
]}

Pagnussat, Gabriela C. ^{[8
]}

Head, Brian ^{[9
,10
]}

Traber, Maret G. ^{[9
,11
]}

Stockwell, Brent R. ^{[12
,13
]}

机构：

[1] Deutsch Forschungszentrum Gesundheit & Umwelt Gmb, Helmholtz Zentrum Munchen, Inst Dev Genet, D-85764 Neuherberg, Germany

[2] Univ Pittsburgh, Ctr Free Radical & Antioxidant Hlth, Pittsburgh, PA 15213 USA

[3] Univ Pittsburgh, Dept Environm Hlth, Pittsburgh, PA 15213 USA

[4] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15213 USA

[5] Univ Pittsburgh, Dept Pharmacol & Chem Biol, Pittsburgh, PA 15213 USA

[6] IM Sechenov First Moscow State Med Univ, Lab Nav Lipid Cell Death & Regenerat, Moscow 119992, Russia

[7] Univ Pittsburgh, Dept Crit Care Med, Pittsburgh, PA 15213 USA

[8] Univ Nacl Mar Del Plata, CONICET, Consejo Nacl Invest Cient & Tecn, Inst Invest Biol, RA-7600 Mar Del Plata, Argentina

[9] Oregon State Univ, Linus Pauling Inst, Corvallis, OR 97330 USA

[10] Oregon State Univ, Mol & Cell Biol Grad Program, Corvallis, OR 97330 USA

[11] Oregon State Univ, Coll Publ Hlth & Human Sci, Corvallis, OR 97330 USA

[12] Columbia Univ, Dept Biol Sci, New York, NY 10027 USA

[13] Columbia Univ, Dept Chem, New York, NY 10027 USA

来源：

GENES & DEVELOPMENT | 2018年 / 32卷 / 9-10期

基金：

美国国家卫生研究院;

关键词：

ferroptosis; lipid peroxidation; cell death; iron; ROS; vitamin E; PROGRAMMED CELL-DEATH; ZEBRAFISH DANIO-RERIO; HYDROPEROXIDE GLUTATHIONE-PEROXIDASE; POLYUNSATURATED FATTY-ACIDS; EGG-YOLK PHOSVITIN; VITAMIN-E CONTENT; OXIDATIVE STRESS; EMBRYONIC LETHALITY; GENE-EXPRESSION; SACCHAROMYCES-CEREVISIAE;

D O I：

10.1101/gad.314674.118

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Lipid peroxidation is the process by which oxygen combines with lipids to generate lipid hydroperoxides via intermediate formation of peroxyl radicals. Vitamin E and coenzyme Q10 react with peroxyl radicals to yield peroxides, and then these oxidized lipid species can be detoxified by glutathione and glutathione peroxidase 4 (GPX4) and other components of the cellular antioxidant defense network. Ferroptosis is a form of regulated nonapoptotic cell death involving overwhelming iron-dependent lipid peroxidation. Here, we review the functions and regulation of lipid peroxidation, ferroptosis, and the antioxidant network in diverse species, including humans, other mammals and vertebrates, plants, invertebrates, yeast, bacteria, and archaea. We also discuss the potential evolutionary roles of lipid peroxidation and ferroptosis.

引用

页码：602 / 619

页数：18

共 222 条

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The oxido-reductase enzyme glutathione peroxidase 4 (GPX4) governs Salmonella Typhimurium-induced neutrophil transepithelial migration [J].