Siglec-mediated regulation of immune cell function in disease

被引：892

作者：

Macauley, Matthew S. ^{[1
,2
,3
]}

Crocker, Paul R. ^{[4
]}

Paulson, James C. ^{[1
,2
,3
]}

机构：

[1] Scripps Res Inst, Dept Cell & Mol Biol, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA

[3] Scripps Res Inst, Dept Physiol Chem, La Jolla, CA 92037 USA

[4] Univ Dundee, Coll Life Sci, Div Cell Signalling & Immunol, Dundee DD1 5EH, Scotland

来源：

NATURE REVIEWS IMMUNOLOGY | 2014年 / 14卷 / 10期

基金：

美国国家卫生研究院; 英国惠康基金;

关键词：

OBSTRUCTIVE PULMONARY-DISEASE; TUMOR-PRODUCED MUCINS; ACID-BINDING LECTIN; CD33-RELATED SIGLECS; GLYCAN LIGANDS; OSTEOCLAST DIFFERENTIATION; GEMTUZUMAB OZOGAMICIN; SIGNALING MOLECULE; COMMON VARIANTS; DEFICIENT MICE;

D O I：

10.1038/nri3737

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

All mammalian cells display a diverse array of glycan structures that differ from those that are found on microbial pathogens. Siglecs are a family of sialic acid-binding immunoglobulin-like receptors that participate in the discrimination between self and non-self, and that regulate the function of cells in the innate and adaptive immune systems through the recognition of their glycan ligands. In this Review, we describe the recent advances in our understanding of the roles of Siglecs in the regulation of immune cell function in infectious diseases, inflammation, neurodegeneration, autoimmune diseases and cancer.

引用

页码：653 / 666

页数：14

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