Clinical and Technical Aspects of Genomic Diagnostics for Precision Oncology

被引：37

作者：

Sheikine, Yuri ^{[1
]}

Kuo, Frank C. ^{[2
]}

Lindeman, Neal I. ^{[2
]}

机构：

[1] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Boston, MA USA

[2] Harvard Med Sch, Brigham & Womens Hosp, Boston, MA USA

来源：

JOURNAL OF CLINICAL ONCOLOGY | 2017年 / 35卷 / 09期

关键词：

MUTATIONS;

D O I：

10.1200/JCO.2016.70.7539

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The emergence of precision medicine has been predicated on significant recent advances in diagnostic technology, particularly the advent of next-generation sequencing (NGS). Although the chemical technology underlying NGS is complex, and the computational biology expertise required to build systems to facilely interpret the results is highly specialized, the variables involved in designing and deploying a genomic testing program for cancer can be readily understood and applied by understanding several basic considerations. In this review, we present key strategic decisions required to optimize a genomic testing program and summarize the technical aspects of different technologies that render those methods more or less suitable for different types of programs. (C) 2017 by American Society of Clinical Oncology

引用

页码：929 / 933

页数：5

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