Functional significance of S6K overexpression in meningiorna progression

被引：30

作者：

Surace, EI ^{[1
]}

Lusis, E ^{[1
]}

Haipek, CA ^{[1
]}

Gutmann, DH ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA

来源：

ANNALS OF NEUROLOGY | 2004年 / 56卷 / 02期

关键词：

D O I：

10.1002/ana.20201

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

One common genetic change in anaplastic meningiomas is amplification of chromosome 17q23 containing the S6 kinase (S6K) gene. We show, for the first time to our knowledge, increased S6K mRNA expression in anaplastic meningiomas compared with benign tumors. To evaluate S6K as a candidate meningioma progression gene, we generated IOMM-Lee human meningioma cell lines overexpressing S6K. Whereas no effect of S6K overexpression on meningioma cell growth, motility, or adhesion was observed in vitro, S6K overexpression resulted in increased tumor size in vivo. Collectively, these results suggest that S6K is functionally important for meningioma progression and may represent a target for future meningioma therapy.

引用

页码：295 / 298

页数：4

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