IRS2 takes center stage in the development of type 2 diabetes

被引：44

作者：

Brady, MJ ^{[1
]}

机构：

[1] Univ Chicago, Dept Med, Comm Mol Metab & Nutr, Chicago, IL 60637 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2004年 / 114卷 / 07期

关键词：

D O I：

10.1172/JC1200423108

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The etiology of type 2 diabetes is characterized by obesity, insulin and leptin resistance, and compensatory P cell hyperplasia followed by islet degeneration, resulting in the eventual dysregulation of glucose and lipid homeostasis. The recent identification of insulin receptor substrate 2 (IRS2) as a central player in the pathophysiology of many of these processes suggests a potentially unifying molecular link underlying the initiation and progression of type 2 diabetes (see the related articles beginning on pages 908 and 917).

引用

页码：886 / 888

页数：3

共 16 条

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