Altered trafficking and epithelial cell polarity in disease

被引:49
作者
Stein, MP [1 ]
Wandinger-Ness, A [1 ]
Roitbak, T [1 ]
机构
[1] Univ New Mexico, Sch Med, Dept Pathol, Mol Trafficking Lab, Albuquerque, NM 87131 USA
关键词
D O I
10.1016/S0962-8924(02)02331-0
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Establishment and maintenance of a polarized epithelium relies on the integration of signaling cascades, acquisition of specialized trafficking circuits and establishment of a unique cytoarchitecture. Defects in any of these processes can adversely affect cell polarity and cause defects in specific organs and systemic disease. Mutations that disrupt the proper transport of individual plasma membrane proteins, or inactivate components of the epithelial-specific trafficking machinery, have severe functional consequences. Links between renal diseases and defects in trafficking, differentiation or signaling, highlight the delicate balance between these parameters which, when altered,
引用
收藏
页码:374 / 381
页数:8
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