Effect of Green Tea and Vitamin E Combination in Isoproterenol Induced Myocardial Infarction in Rats

被引：82

作者：

Upaganlawar, Aman ^{[2
]}

Gandhi, Chintan ^{[2
]}

Balaraman, Ramchandran ^{[1
,2
]}

机构：

[1] Maharaja Sayajirao Univ Baroda, Dept Pharm, Fac Engn & Technol, Vadodara 390001, Gujarat, India

[2] Maharaja Sayajirao Univ Baroda, Fac Engn & Technol, Dept Pharm, Vadodara 390002, Gujarat, India

来源：

PLANT FOODS FOR HUMAN NUTRITION | 2009年 / 64卷 / 01期

关键词：

Antioxidants; ATPases; Green tea; Isoproterenol; Vitamin E; GLUTATHIONE; LUNG;

D O I：

10.1007/s11130-008-0105-9

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The present Study was aimed to investigate the combined effects of green tea and vitamin E on heart weight, body weight, serum marker enzymes, lipid peroxidation, endogenous antioxidants and membrane bound ATPases in isoproterenol (ISO)-induced myocardial infarction in rats. Adult male albino rats, treated with ISO (200 mg/kg, s.c.) for 2 days at all interval of 24 h caused a significant (P<0.05) elevation of heart weight, serum marker enzymes, lipid peroxidation and Ca+2 ATPase level whereas there was a significant (P<0.05) decrease in body weight, endogenous antioxidants, Na+/K+ ATPase and Mg+2 ATPase levels. Administration of green tea (100 mg/kg/day, p.o.) and vitamin E (100 mg/kg/day, p.o.) together for 30 consecutive days and challenged with ISO on the day 29th and 30th, showed a significant (P<0.05) decrease in heart weight, serum marker enzymes, lipid peroxidation, Ca+2 ATPase and a significant increase in the body weight, endogenous antioxidants, Na+/K+ ATPase and Mg+2 ATPase when compared with ISO treated group and green tea or vitamin E alone treated groups. These findings indicate the synergistic protective effect of green tea and vitamin E during ISO induced myocardial infarction in rats.

引用

页码：75 / 80

页数：6

共 30 条

[1]

AEBI H, 1984, METHOD ENZYMOL, V105, P121

[2]

Anurag P., 2003, PLANT FOOD HUM NUTR, V58, P1, DOI DOI 10.1023/B:QUAL.0000040363.64356.05

[3] Pyruvate provides cardioprotection in the experimental model of myocardial ischemic reperfusion injury [J].

Arya, Dharamvir Singh ;

Bansal, Pankaj ;

Ojha, Shreesh Kumar ;

Nandave, Mukesh ;

Mohanty, Ipseeta ;

Gupta, Suresh Kumar .

LIFE SCIENCES, 2006, 79 (01) :38-44

[4]

BONTING SL, 1970, BIOBEHAVIOURAL BASE, V1, P254

[5] Diagnosis and management of bradycardia and atrioventricular block associated with acute coronary ischemia [J].

Brady, WJ ;

Harrigan, RA .

EMERGENCY MEDICINE CLINICS OF NORTH AMERICA, 2001, 19 (02) :371-+

[6] Determination of In vitro antidiabetic effects, antioxidant activities and phenol contents of some herbal teas [J].

Bueyuekbalci, Aynur ;

El, Sedef Nehir .

PLANT FOODS FOR HUMAN NUTRITION, 2008, 63 (01) :27-33

[7] Vitamin E in human health and disease [J].

Clarke, Michael W. ;

Burnett, John R. ;

Croft, Kevin D. .

CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES, 2008, 45 (05) :417-450

[8]

Habig W H, 1981, Methods Enzymol, V77, P398

[9] PURIFICATION AND CHARACTERIZATION OF 2 FORMS OF A LOW-AFFINITY CA2+-ATPASE FROM ERYTHROCYTE-MEMBRANES [J].

HJERTEN, S ;

PAN, H .

BIOCHIMICA ET BIOPHYSICA ACTA, 1983, 728 (02) :281-288

[10] Preventive effects of green tea on renal stone formation and the role of oxidative stress in nephrolithiasis [J].

Itoh, Y ;

Yasui, T ;

Okada, A ;

Tozawa, K ;

Hayashi, Y ;

Kohri, K .

JOURNAL OF UROLOGY, 2005, 173 (01) :271-275

← 1 2 3 →