Synthesis of 2-azabicyclo[3.3.1]nonanes by means of (carbamoyl)dichloromethyl radical cyclization

被引：53

作者：

Quirante, J ^{[1
]}

Escolano, C ^{[1
]}

Massot, M ^{[1
]}

Bonjoch, J ^{[1
]}

机构：

[1] UNIV BARCELONA,FAC FARM,ORGAN CHEM LAB,E-08028 BARCELONA,SPAIN

来源：

TETRAHEDRON | 1997年 / 53卷 / 04期

关键词：

D O I：

10.1016/S0040-4020(96)01051-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new procedure for the synthesis of 2-azabicyclo[3.3.1]nonanes by intramolecular carboradical cyclization of 4-(trichloroacetamido)cyclohexenes substituted with an electron withdrawing substituent (ester or nitrile) is described. The procedure allows the preparation of synthetically interesting azabicyclos 14 and 15 in nearly 70% yield. (C) 1997, Elsevier Science Ltd.

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页码：1391 / 1402

页数：12

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