Loss of atheroprotective effect of estradiol in immunodeficient mice.

被引：28

作者：

Elhage, R

Clamens, S

Reardon-Alulis, C

Getz, GS

Fievet, C

Maret, A

Arnal, JF

Bayard, F

机构：

[1] Inst L BUGNARD, INSERM, U397, F-31054 Toulouse, France

[2] Inst Pasteur, SERLIA, INSERM, U315, F-59019 Lille, France

[3] Univ Chicago, Dept Pathol, Chicago, IL 60637 USA

来源：

ENDOCRINOLOGY | 2000年 / 141卷 / 01期

关键词：

D O I：

10.1210/en.141.1.462

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Estradiol significantly decreases fatty streak formation in the aortic root of chow-fed apolipoprotein E-deficient mice. In contrast, immunodeficient mice with homozygous disruption at the recombinase activating gene 2 loci present fatty streak development that is insensitive to estradiol. Lymphocytes thus appear to be required for development of the atheroprotective effect of estradiol in this mouse model.

引用

页码：462 / 465

页数：4

共 12 条

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