Treatment of Cardiorenal Syndrome

被引：25

作者：

Rubinstein, Jack ^{[1
]}

Sanford, Darek ^{[1
]}

机构：

[1] Univ Cincinnati, Med Sci Bldg,231 Albert Sabin Way,MLC 0542, Cincinnati, OH 45267 USA

来源：

CARDIOLOGY CLINICS | 2019年 / 37卷 / 03期

关键词：

Cardiorenal syndrome; Systolic dysfunction; Diastolic dysfunction; Heart failure; Acute kidney injury; Chronic kidney disease; Worsening renal function; CONGESTIVE-HEART-FAILURE; WORSENING RENAL-FUNCTION; DOUBLE-BLIND; DARBEPOETIN-ALPHA; MORTALITY; NESIRITIDE; SURVIVAL; OUTCOMES; LEVOSIMENDAN; ADMISSION;

D O I：

10.1016/j.ccl.2019.04.002

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

The treatment of cardiorenal syndrome is as complex as the various mechanisms underlying its pathophysiology. Randomized controlled data typically focus on the treatment of heart failure with cardiac specific endpoints and a lack of worsening renal function used as a surrogate for efficacy. When heart failure is considered the inciting event, the acute state is managed with vasodilators, inotropic support, and decongestion; whereas neurohormonal axis inhibition is more commonly applied to chronic state. A recent shift in thought process regarding the interplay of cardiac and renal dysfunction suggests that renal congestion may be the primary driver of worsening renal function.

引用

页码：267 / +

页数：8

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