Prime movers: the mechanochemistry of mitotic kinesins

被引：156

作者：

Cross, Robert A. ^{[1
]}

McAinsh, Andrew ^{[1
]}

机构：

[1] Warwick Med Sch, Coventry CV4 7AL, W Midlands, England

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2014年 / 15卷 / 04期

基金：

英国生物技术与生命科学研究理事会;

关键词：

BIPOLAR SPINDLE FORMATION; CENP-E; CENTROSOME SEPARATION; DEPOLYMERIZES MICROTUBULES; CHROMOSOME CONGRESSION; ALLOSTERIC INHIBITOR; SELF-ORGANIZATION; CHROMOKINESIN KID; FORCE GENERATION; STRUCTURAL MODEL;

D O I：

10.1038/nrm3768

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Mitotic spindles are self-organizing protein machines that harness teams of multiple force generators to drive chromosome segregation. Kinesins are key members of these force-generating teams. Different kinesins walk directionally along dynamic microtubules, anchor, crosslink, align and sort microtubules into polarized bundles, and influence microtubule dynamics by interacting with microtubule tips. The mechanochemical mechanisms of these kinesins are specialized to enable each type to make a specific contribution to spindle self-organization and chromosome segregation.

引用

页码：257 / 271

页数：15

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