Simvastatin increases osteoblasts and osteogenic proteins in ovariectomized rats

被引：67

作者：

Ho, M. -L. ^{[1
]}

Chen, Y. -H. ^{[1
]}

Liao, H. -J. ^{[1
]}

Chen, C. -H. ^{[1
]}

Hung, S. -H. ^{[1
,2
]}

Lee, M. -J. ^{[1
,3
]}

Fu, Y. -C. ^{[1
]}

Wang, Y. -H. ^{[1
,2
]}

Wang, G. -J. ^{[3
]}

Chang, J. -K. ^{[1
]}

机构：

[1] Kaohsiung Med Univ, Kaohsiung, Taiwan

[2] Fooyin Univ Hosp, Tungkang Chen, Ping Tung Cty, Taiwan

[3] Natl Cheng Kung Univ, Tainan 70101, Taiwan

来源：

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION | 2009年 / 39卷 / 04期

关键词：

Bone formation; osteoblasts; osteogenic proteins; ovariectomy; simvastatin; POSTMENOPAUSAL WOMEN; BONE-FORMATION; MC3T3-E1; CELLS; STATINS; OSTEOPOROSIS; EXPRESSION; HISTOMORPHOMETRY; DIFFERENTIATION; OSTEOCALCIN; PRAVASTATIN;

D O I：

10.1111/j.1365-2362.2009.02092.x

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Previous reports have indicated that statins could prevent bone loss in ovariectomized (OVX) rats and increase the expressions of osteogenic genes in cultured osteoblasts. In this study, we hypothesized that simvastatin might increase osteoblast number and protein expressions of osteogenic markers localized in bones in concomitance with the prevention of bone loss in OVX rats. Fifty-four 3-month-old OVX and sham-operated (SHAM) female Sprague-Dawley rats were used. Simvastatin (10-20 mg kg(-1) day(-1)) was administrated orally for 6 weeks. Trabecular volume, osteoblast number and osteogenic proteins including BMP2, collagen type I and osteocalcin on bone sections obtained from lumbar vertebral body, distal femur and proximal tibia were measured. The results showed that SHAM rats had significantly less trabecular bone volume and osteoblast number than that of OVX rats 6 weeks after operation. Oral simvastatin treatment (10-20 mg kg(-1) day(-1)) increased bone volume and osteoblast number in the distal femurs, proximal tibiae and vertebrae of OVX rats. Furthermore, the osteoblastic cells with immuno-stained BMP2, collagen type I and osteocalcin in vertebral bones were significantly increased by simvastatin treatment (20 mg kg(-1) day(-1)) in OVX rats. This study demonstrates that simvastatin enhances the production of osteogenic proteins in bone and this effect may contribute to the prevention of bone loss in OVX rats.

引用

页码：296 / 303

页数：8

共 32 条

[1]

Pharmacological prevention of atherothrombotic events in patients with peripheral arterial disease [J].