Epithelial-mesenchymal transition in lung development and disease: does it exist and is it important?

被引：305

作者：

Bartis, Domokos ^{[1
]}

Mise, Nikica ^{[2
,3
]}

Mahida, Rahul Y. ^{[1
]}

Eickelberg, Oliver ^{[2
,3
]}

Thickett, David R. ^{[1
]}

机构：

[1] Univ Birmingham, Ctr Translat Inflammat & Fibrosis Res, Dept Clin Resp Sci, Sch Clin & Expt Med, Birmingham B15 2WB, W Midlands, England

[2] Univ Munich, Comprehens Pneumol Ctr, Univ Hosp, Munich, Germany

[3] Helmholtz Zentrum, Munich, Germany

来源：

THORAX | 2014年 / 69卷 / 08期

关键词：

IDIOPATHIC PULMONARY-FIBROSIS; GROWTH-FACTOR-BETA; TRANSCRIPTION FACTOR SLUG; SMOOTH-MUSCLE-CELLS; TGF-BETA; CIGARETTE-SMOKE; EXTRACELLULAR-MATRIX; AIRWAY; ASTHMA; CANCER;

D O I：

10.1136/thoraxjnl-2013-204608

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

100201 [内科学];

摘要：

Epithelial-mesenchymal transition (EMT) is a process when epithelial cells gradually transform into mesenchymal-like cells losing their epithelial functionality and characteristics. EMT is thought to be involved in the pathogenesis of numerous lung diseases ranging from developmental disorders, fibrotic tissue remodelling to lung cancer. The most important question-namely what is the importance and contribution of EMT in the pathogenesis of several chronic lung conditions (asthma, COPD, bronchiolitis obliterans syndrome and lung fibrosis)-is currently intensely debated. This review gives a brief insight into the mechanism and assessment methods of EMT in various pulmonary diseases and summarises the recent literature highlighting the controversial experimental data and conclusions.

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收藏

页码：760 / 765

页数：6

相关论文

共 89 条

[1]

Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease [J].

Acloque, Herve ;

Adams, Meghan S. ;

Fishwick, Katherine ;

Bronner-Fraser, Marianne ;

Angela Nieto, M. .

JOURNAL OF CLINICAL INVESTIGATION, 2009, 119 (06) :1438-1449

[2]

Current and novel drug therapies for idiopathic pulmonary fibrosis [J].

Adamali, Huzaifa I. ;

Maher, Toby M. .

DRUG DESIGN DEVELOPMENT AND THERAPY, 2012, 6 :261-271

[3]

Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis [J].

Akhmetshina, Alfiya ;

Palumbo, Katrin ;

Dees, Clara ;

Bergmann, Christina ;

Venalis, Paulius ;

Zerr, Pawel ;

Horn, Angelika ;

Kireva, Trayana ;

Beyer, Christian ;

Zwerina, Jochen ;

Schneider, Holm ;

Sadowski, Anika ;

Riener, Marc-Oliver ;

MacDougald, Ormond A. ;

Distler, Oliver ;

Schett, Georg ;

Distler, Joerg H. W. .

NATURE COMMUNICATIONS, 2012, 3

[4]

Morphogenesis of epithelial tubes: Insights into tube formation, elongation, and elaboration [J].

Andrew, Deborah J. ;

Ewald, Andrew J. .

DEVELOPMENTAL BIOLOGY, 2010, 341 (01) :34-55

[5]

Down-Regulation of Canonical and Up-Regulation of Non-Canonical Wnt Signalling in the Carcinogenic Process of Squamous Cell Lung Carcinoma [J].

Bartis, Domokos ;

Csongei, Veronika ;

Weich, Alexander ;

Kiss, Edit ;

Barko, Szilvia ;

Kovacs, Tamas ;

Avdicevic, Monika ;

D'Souza, Vijay K. ;

Rapp, Judit ;

Kvell, Krisztian ;

Jakab, Laszlo ;

Nyitrai, Miklos ;

Molnar, Tamas F. ;

Thickett, David R. ;

Laszlo, Terezia ;

Pongracz, Judit E. .

PLOS ONE, 2013, 8 (03)

[6]

EMT in carcinoma progression and dissemination: Facts, unanswered questions, and clinical considerations [J].

Bastid, Jeremy .

CANCER AND METASTASIS REVIEWS, 2012, 31 (1-2) :277-283

[7]

Pseudomonas aeruginosa accentuates epithelial-to-mesenchymal transition in the airway [J].

Borthwick, L. A. ;

Sunny, S. S. ;

Oliphant, V. ;

Perry, J. ;

Brodlie, M. ;

Johnson, G. E. ;

Ward, C. ;

Gould, K. ;

Corris, P. A. ;

De Soyza, A. ;

Fisher, A. J. .

EUROPEAN RESPIRATORY JOURNAL, 2011, 37 (05) :1237-1247

[8]

Epithelial to mesenchymal transition (EMT) and airway remodelling after human lung transplantation [J].

Borthwick, L. A. ;

Parker, S. M. ;

Brougham, K. A. ;

Johnson, G. E. ;

Gorowiec, M. R. ;

Ward, C. ;

Lordan, J. L. ;

Corris, P. A. ;

Kirby, J. A. ;

Fisher, A. J. .

THORAX, 2009, 64 (09) :770-777

[9]

Organization and formation of the tight junction system in human epidermis and cultured keratinocytes [J].

Brandner, JM ;

Kief, S ;

Grund, C ;

Rendl, M ;

Houdek, P ;

Kuhn, C ;

Tschachler, E ;

Franke, WW ;

Moll, I .

EUROPEAN JOURNAL OF CELL BIOLOGY, 2002, 81 (05) :253-263

[10]

Targeting TGFβ superfamily ligand accessory proteins as novel therapeutics for chronic lung disorders [J].

Budd, David C. ;

Holmes, Alan M. .

PHARMACOLOGY & THERAPEUTICS, 2012, 135 (03) :279-291

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