What has been learnt from study of dopamine receptors in Parkinson's disease?

被引：90

作者：

Hurley, M. J. ^{[1
]}

Jenner, P. ^{[1
]}

机构：

[1] Kings Coll London, Neurodegerat Dis Res Grp, Sch Biomed & Hlth Sci, London SE1 1UL, England

来源：

PHARMACOLOGY & THERAPEUTICS | 2006年 / 111卷 / 03期

关键词：

Parkinson's disease; dopamine receptors; dopamine agonists; L-DOPA;

D O I：

10.1016/j.pharmthera.2005.12.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Since the introduction of dopamine replacement therapy using L-3,4-dihydroxyphenyalanine (L-DOPA) to treat Parkinson's disease and the recognition of the problems associated with L-DOPA use, numerous studies have investigated dopamine receptor regulation and function in Parkinson's disease. These studies have provided insight into the pathological process of the disorder and the molecular consequences of chronic dopaminergic treatment, but they have been less successful in identifying new pharmacological targets or treatment regimes that are as effective as L-DOPA at alleviating the symptoms of Parkinson's disease. This review will present a summary of the reported changes in dopamine receptor regulation and function that occur in Parkinson's disease and will discuss their contribution to the current pharmacological management of Parkinson's disease. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：715 / 728

页数：14

共 178 条

[1] Regulation of dopamine D1-receptor activation in vivo by protein phosphatase 2B (calcineurin) [J].

Adlersberg, M ;

Hsiung, SC ;

Glickstein, SB ;

Liu, KP ;

Tamir, H ;

Schmauss, C .

JOURNAL OF NEUROCHEMISTRY, 2004, 90 (04) :865-873

[2] REDUCED D2 DOPAMINE AND MUSCARINIC CHOLINERGIC RECEPTOR DENSITIES IN CAUDATE SPECIMENS FROM FLUCTUATING PARKINSONIAN-PATIENTS [J].

AHLSKOG, JE ;

RICHELSON, E ;

NELSON, A ;

KELLY, PJ ;

OKAZAKI, H ;

TYCE, GM ;

VANHEERDEN, JA ;

STODDARD, SL ;

CARMICHAEL, SW .

ANNALS OF NEUROLOGY, 1991, 30 (02) :185-191

[3] Frequency of levodopa-related dyskinesias and motor fluctuations as estimated from the cumulative literature [J].

Ahlskog, JE ;

Muenter, MD .

MOVEMENT DISORDERS, 2001, 16 (03) :448-458

[4] Anatomical and physiological evidence for D1 and D2 dopamine receptor colocalization in neostriatal neurons [J].

Aizman, O ;

Brismar, H ;

Uhlén, P ;

Zettergren, E ;

Levey, AI ;

Forssberg, H ;

Greengard, P ;

Aperia, A .

NATURE NEUROSCIENCE, 2000, 3 (03) :226-230

[5] THE FUNCTIONAL-ANATOMY OF BASAL GANGLIA DISORDERS [J].

ALBIN, RL ;

YOUNG, AB ;

PENNEY, JB .

TRENDS IN NEUROSCIENCES, 1989, 12 (10) :366-375

[6] Long-term changes of striatal dopamine D-2 receptors in patients with Parkinson's disease: A study with positron emission tomography and [C-11]Raclopride [J].

Antonini, A ;

Schwarz, J ;

Oertel, WH ;

Pogarell, O ;

Leenders, KL .

MOVEMENT DISORDERS, 1997, 12 (01) :33-38

[7]

Ariano MA, 1997, SYNAPSE, V26, P400, DOI 10.1002/(SICI)1098-2396(199708)26:4<400::AID-SYN8>3.0.CO

[8]

2-A

[9] DOPAMINE-RECEPTOR DISTRIBUTION IN THE RAT CNS - ELUCIDATION USING ANTIPEPTIDE ANTISERA DIRECTED AGAINST D-1A AND D-3 SUBTYPES [J].

ARIANO, MA ;

SIBLEY, DR .

BRAIN RESEARCH, 1994, 649 (1-2) :95-110

[10] Increased D1 dopamine receptor signaling in levodopa-induced dyskinesia [J].

Aubert, I ;

Guigoni, C ;

Håkansson, K ;

Li, Q ;

Dovero, S ;

Barthe, N ;

Bioulac, BH ;

Gross, CE ;

Fisone, G ;

Bloch, B ;

Bezard, E .

ANNALS OF NEUROLOGY, 2005, 57 (01) :17-26

← 1 2 3 4 5 6 7 8 9 10 →