The androgen receptor in spermatogenesis

被引:42
作者
Collins, LL
Lee, HJ
Chen, YT
Chang, M
Hsu, HY
Yeh, S
Chang, C
机构
[1] Univ Rochester, George H Whipple Lab Canc Res, Dept Urol, Rochester, NY 14642 USA
[2] Univ Rochester, George H Whipple Lab Canc Res, Dept Radiat Oncol, Rochester, NY 14642 USA
[3] Natl Dong Hwa Univ, Inst Biotechnol, Hualien, Taiwan
[4] Natl Dong Hwa Univ, Dept Life Sci, Hualien, Taiwan
[5] Chang Gung Mem Hosp, Kaohsiung, Taiwan
[6] Tzu Chi Univ, Inst Med Sci, Hualien, Taiwan
[7] Tzu Chi Univ, Dept Life Sci, Hualien, Taiwan
关键词
D O I
10.1159/000076816
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Androgens are steroid hormones that are necessary for normal male phenotype expression, including the outward development of secondary sex characteristics as well as the initiation and maintenance of spermatogenesis. Many physiological actions of androgens are mediated by the androgen receptor (AR), a member of the nuclear receptor superfamily. AR functions as a ligand-dependent transcription factor, regulating expression of an array of target genes that are important in male pubertal development and fertility. In this review, the expression and necessity of EAR in specific testicular cell types that are important in spermatogenesis will be discussed, and recent information obtained through the study of complete and cell type-specific AR null mouse models will be presented. Copyright (C) 2003 S. Karger AG, Basel.
引用
收藏
页码:299 / 301
页数:3
相关论文
共 30 条
[1]   ANALYSIS OF THE ANDROGEN RECEPTOR IN ISOLATED TESTICULAR CELL-TYPES WITH A MICROASSAY THAT USES AN AFFINITY LIGAND [J].
ANTHONY, CT ;
KOVACS, WJ ;
SKINNER, MK .
ENDOCRINOLOGY, 1989, 125 (05) :2628-2635
[2]   IMMUNOHISTOCHEMICAL LOCALIZATION OF ANDROGEN RECEPTORS IN THE RAT TESTIS - EVIDENCE FOR STAGE-DEPENDENT EXPRESSION AND REGULATION BY ANDROGENS [J].
BREMNER, WJ ;
MILLAR, MR ;
SHARPE, RM ;
SAUNDERS, PTK .
ENDOCRINOLOGY, 1994, 135 (03) :1227-1234
[3]   STRUCTURAL-ANALYSIS OF COMPLEMENTARY-DNA AND AMINO-ACID SEQUENCES OF HUMAN AND RAT ANDROGEN RECEPTORS [J].
CHANG, CS ;
KOKONTIS, J ;
LIAO, SS .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (19) :7211-7215
[4]   MOLECULAR-CLONING OF HUMAN AND RAT COMPLEMENTARY-DNA ENCODING ANDROGEN RECEPTORS [J].
CHANG, CS ;
KOKONTIS, J ;
LIAO, SS .
SCIENCE, 1988, 240 (4850) :324-326
[5]  
CHANG JA, 2002, ANDROGENS ANDROGEN R, P289
[6]  
Collins LL., 2002, ANDROGENS ANDROGEN R, P299, DOI 10.1007/978-1-4615-1161-8_14
[7]  
De Kretser D. M., 1994, P1177
[8]   INTERACTIONS BETWEEN GERM-CELLS AND SERTOLI CELLS IN THE TESTIS [J].
GRISWOLD, MD .
BIOLOGY OF REPRODUCTION, 1995, 52 (02) :211-216
[9]   ABSENCE OF A NUCLEAR ANDROGEN RECEPTOR IN ISOLATED GERMINAL CELLS OF RAT TESTIS [J].
GROOTEGOED, JA ;
PETERS, MJ ;
MULDER, E ;
ROMMERTS, FFG ;
VANDERMOLEN, HJ .
MOLECULAR AND CELLULAR ENDOCRINOLOGY, 1977, 9 (02) :159-167
[10]   Androgen receptor (AR) coregulators: An overview [J].
Heinlein, CA ;
Chang, CS .
ENDOCRINE REVIEWS, 2002, 23 (02) :175-200