A highly stereospecific and efficient synthesis of homopentafluorophenylalanine

被引：7

作者：

Babu, IR ^{[1
]}

Hamill, EK ^{[1
]}

Kumar, K ^{[1
]}

机构：

[1] Tufts Univ, Dept Chem, Medford, MA 02155 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2004年 / 69卷 / 16期

关键词：

D O I：

10.1021/jo049206z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A short and efficient synthesis of homopentafluorophenylalanine (6) from oxazolidine aldehyde 1 in 57% overall yield and in >98% ee is described. The enantiomeric excess of the product was determined by F-19 NMR analysis of the coupling product derived from 5 and L-Ser(O-t-Bu)OCH3, by comparison to a dipeptide obtained from racemic 5.

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收藏

页码：5468 / 5470

页数：3

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