A new synthesis of α-methylspermidine

被引：4

作者：

Grigorenko, NA

Vepsalainen, J

Jarvinen, A

Keinanen, TA

Alhonen, L

Janne, J

Kritsyn, AM

Khomutov, AR

机构：

[1] Russian Acad Sci, VA Engelhardt Mol Biol Inst, Moscow 119991, Russia

[2] Univ Kuopio, Dept Chem, FIN-70211 Kuopio, Finland

[3] Univ Kuopio, Virtanen Inst Mol Sci, FIN-70211 Kuopio, Finland

来源：

RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY | 2004年 / 30卷 / 04期

基金：

俄罗斯基础研究基金会; 芬兰科学院;

关键词：

alpha-methylspermidine; polyamines; spermine/spermidine N-1-acetyltransferase;

D O I：

10.1023/B:RUBI.0000037268.98349.ce

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A five-step synthesis of alpha-methylspermidine (1,8-diamino-5-azanonane), the first polyamine analogue preventing pathological consequences of spermidine depletion in transgenic rats overproducing spermine/spermidine N-1-acetyltransferase, from ethyl 3-aminobutyrate was achieved in a high overall yield.

引用

收藏

页码：396 / 399

页数：4

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