Supramolecular assemblies based on copolymers of PEG600 and functionalized aromatic diesters for drug delivery applications

被引:104
作者
Kumar, R
Chen, MH
Parmar, VS [1 ]
Samuelson, LA
Kumar, J
Nicolosi, R
Yoganathan, S
Watterson, AC
机构
[1] Univ Massachusetts, Inst Nanosci & Engn Technol, Dept Chem, Lowell, MA 01854 USA
[2] Univ Massachusetts, Ctr Adv Mat, Dept Chem, Lowell, MA 01854 USA
[3] Univ Delhi, Dept Chem, Bioorgan Lab, Delhi 110007, India
[4] USA, Natick Soldier Ctr, Soldier & Biol Chem Command, Natick, MA 01760 USA
[5] Univ Massachusetts, Dept Hlth & Clin Sci, Lowell, MA 01854 USA
关键词
D O I
10.1021/ja039651w
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A chemoenzymatic approach has been developed to synthesize poly(ethylene glycol)-based amphiphilic copolymers under mild reaction conditions that self-assemble in aqueous media to form polymeric nanomicelles in the range of 20-50 nm. The supramolecular organization of polymeric nanomicelles was studied by H-1 NMR longitudinal relaxation time (T-1) and light scattering techniques (static and dynamic). Interestingly, the enzyme novozyme-435 plays an important role in controlling the polymerization and distribution of polymer chains, which is critical for the formation of nanomicelles with unimodal distributions. The methodology developed is highly flexible as it allows the introduction of various functionalities in the polymeric nanomicelles. These self-organized nanomicelles are highly efficient drug delivery vehicles for hydrophobic and partially hydrophilic drugs, both transdermally and orally, as they have the ability to encapsulate guest molecules during self-organization. In vivo studies by encapsulating anti-inflammatory agents (aspirin and naproxen) in these polymeric nanomicelles and by applying topically resulted in significant reduction in inflammation. The % reduction in inflammation using polymeric nanomicelles containing aspirin and naproxen was 62 and 64%, respectively.
引用
收藏
页码:10640 / 10644
页数:5
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