Genetics of alcohol withdrawal

被引：33

作者：

Schmidt, LG ^{[1
]}

Sander, T ^{[1
]}

机构：

[1] Free Univ Berlin, Dept Psychiat, D-14050 Berlin, Germany

来源：

EUROPEAN PSYCHIATRY | 2000年 / 15卷 / 02期

关键词：

alcoholism; dopamine; GABA; genes; genetics; opioids; serotonin; withdrawal;

D O I：

10.1016/S0924-9338(00)00220-0

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Alcohol withdrawal is a clinically and etiologically heterogeneous syndrome caused by a complex interaction of environmental (e.g., amount of ethanol) and genetic factors. Multiple genes are considered to be involved in various components of the syndrome, each of them contributing only modestly to withdrawal vulnerability. Association studies using candidate genes of the dopamine, serotonin, gabaergic and opioidergic systems are reviewed and methodological limitations are discussed. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

引用

页码：135 / 139

页数：5

共 42 条

[1] ALLELIC ASSOCIATION OF HUMAN DOPAMINE-D2 RECEPTOR GENE IN ALCOHOLISM [J].

BLUM, K ;

NOBLE, EP ;

SHERIDAN, PJ ;

MONTGOMERY, A ;

RITCHIE, T ;

JAGADEESWARAN, P ;

NOGAMI, H ;

BRIGGS, AH ;

COHN, JB .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1990, 263 (15) :2055-2060

[2] Single-nucleotide polymorphism in the human mu opioid receptor gene alters β-endorphin binding and activity:: Possible implications for opiate addiction [J].

Bond, C ;

LaForge, KS ;

Tian, MT ;

Melia, D ;

Zhang, SW ;

Borg, L ;

Gong, JH ;

Schluger, J ;

Strong, JA ;

Leal, SM ;

Tischfield, JA ;

Kreek, MJ ;

Yu, L .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (16) :9608-9613

[3]

Bonhoeffer K., 1901, AKUTEN GEISTESKRANKH

[4] Sound-induced seizures in serotonin 5-HT2C receptor mutant mice [J].

Brennan, TJ ;

Seeley, WW ;

Kilgard, M ;

Schreiner, CE ;

Tecott, LH .

NATURE GENETICS, 1997, 16 (04) :387-390

[5] Can we subtype alcoholism? A latent class analysis of data from relatives of alcoholics in a multicenter family study of alcoholism [J].

Bucholz, KK ;

Heath, AC ;

Reich, T ;

Hesselbrock, VM ;

Kramer, JR ;

Nurnberger, JI ;

Schuckit, MA .

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 1996, 20 (08) :1462-1471

[6]

Buck KJ, 1997, J NEUROSCI, V17, P3946

[7] Ethanol reward and aversion in mice bred for sensitivity to ethanol withdrawal [J].

Chester, JA ;

Risinger, FO ;

Cunningham, CL .

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 1998, 22 (02) :468-473

[8] GENETIC ANIMAL-MODELS OF ALCOHOL AND DRUG-ABUSE [J].

CRABBE, JC ;

BELKNAP, JK ;

BUCK, KJ .

SCIENCE, 1994, 264 (5166) :1715-1723

[9]

Dilling H, 1993, WHO INT KLASSIFIKATI

[10]

EBSTEIN RP, 1997, MOL PSYCHIATR, V2, P382

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