Synthesis and vasorelaxant activity of new 1,4-benzoxazine derivatives potassium channel openers

被引：36

作者：

Caliendo, G

Perissutti, E

Santagada, V

Fiorino, F

Severino, B

Bianca, RDD

Lippolis, L

Pinto, A

Sorrentino, R

机构：

[1] Univ Naples, Dipartimento Chim Farmaceut & Tossicol, I-80131 Naples, Italy

[2] Univ Naples Federico II, Dipartimento Sperimentale, I-80131 Naples, Italy

[3] Univ Salerno, Dipartimento Sci Farmaceut, Fisciano, SA, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2002年 / 10卷 / 08期

关键词：

D O I：

10.1016/S0968-0896(02)00091-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

As part of a search for new potassium channel openers, the synthesis and vasorelaxant activity of new 1,4-benzoxazilic derivatives derived from transformation of the benzopyran skeleton of cromakalim were described. Several new 1,4-benzoxazine derivatives were provided with significant vasorelaxant activity with an overall pharmacological behavior similar to CRK (1f, 1i, 2d, 2e, 2f and 2i). (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：2663 / 2669

页数：7

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