CDH1 c-160a promotor polymorphism is not associated with risk of stomach cancer

被引：49

作者：

Pharoah, PDP

Oliveira, C

Machado, JC

Keller, G

Vogelsang, H

Laux, H

Becker, KF

Hahn, H

Paproski, SM

Brown, LA

Caldas, C

Huntsman, D

机构：

[1] Univ Cambridge, Strangeways Res Labs, Dept Oncol, Cambridge CB1 8RN, England

[2] IPATIMUP, Oporto, Portugal

[3] Tech Univ Munich, Inst Pathol, D-8000 Munich, Germany

[4] Tech Univ Munich, Dept Surg, D-8000 Munich, Germany

[5] GSF, Natl Res Ctr Environm & Hlth, Inst Pathol, Oberschleissheim, Germany

[6] Vancouver Gen Hosp, Dept Pathol & Lab Med, Vancouver, BC, Canada

[7] Vancouver Gen Hosp, Prostate Res Ctr, Vancouver, BC, Canada

[8] Univ Cambridge, Dept Oncol, Cambridge Inst Med Res, Cambridge, England

[9] British Columbia Canc Agcy, Vancouver, BC V5Z 4E6, Canada

来源：

INTERNATIONAL JOURNAL OF CANCER | 2002年 / 101卷 / 02期

关键词：

stomach cancer; CDH1; polymorphism; susceptibility;

D O I：

10.1002/ijc.10590

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We have combined data from case control studies designed to test the hypothesis that the c-160a promotor polymorphism in the gene coding for the cell adhesion molecule E-cadherin (CDH1) is associated with stomach cancer. A total of 899 individuals (433 patients and 466 controls) were analyzed. The genotype frequencies did not differ significantly between cases and controls, and the genotype-specific risks were not significantly different from unity, with an odds ratio for heterozygotes compared with the common homozygote of 1.3 (95% Cl 0.98-1.8) and 1.2 (0.68-2.0) for rare homozygotes compared with common homozygotes. We found no evidence for differences in risk for the intestinal- and diffuse-type histopathologic subgroups. (C) 2002 Wiley-Liss, Inc.

引用

页码：196 / 197

页数：2

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