Clearance of Serum HBsAg and Anti-HBs Seroconversion Following Antiviral Therapy for Chronic Hepatitis B

被引：29

作者：

Borgniet, Olivier ^{[2
]}

Parvaz, Parviz ^{[3
]}

Bouix, Cecile ^{[2
]}

Chevallier, Philippe ^{[3
]}

Trepo, Christian ^{[2
]}

Andre, Patrice ^{[1
,3
]}

Zoulim, Fabien ^{[1
,2
]}

机构：

[1] Univ Lyon 1, INSERM, U871, Biosci Lyon Gerland IFR128, F-69424 Lyon 03, France

[2] Hosp Civils Lyon, Serv Hepatol & Gastroenterol, Lyon, France

[3] Hop Croix Rousse, Hosp Civils Lyon, Lab Virol Nord, F-69317 Lyon, France

来源：

JOURNAL OF MEDICAL VIROLOGY | 2009年 / 81卷 / 08期

关键词：

hepatitis B virus; treatment monitoring; serological assay; SURFACE-ANTIGEN; COMBINATION THERAPY; VIRUS-INFECTION; DNA LEVELS; HBEAG; LAMIVUDINE; ADEFOVIR; SEROCLEARANCE; PERSISTENCE; DECLINE;

D O I：

10.1002/jmv.21519

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In this study, we have analyzed the evolution of serum HBsAg levels in 16 patients with chronic hepatitis B who showed an HBsAg seroconversion following antiviral therapy. The data showed that the clearance of serum HBsAg is slower than that of serum HBV DNA, which may reflect a slow kinetics of clearance of infected hepatocytes. Interestingly, HBsAg was detectable for a longer time using the Architect assay than with the Bio-Rad assay. As viremia suppression is achieved in most patients under therapy with the new generation of nucleoside analogs, these data suggest that the quantitative monitoring of serum HBsAg may represent a novel tool for the assessment of antiviral therapy efficacy. J.Med. ViroL 81:1336-1342,2009. (C) 2009 Wiley-Liss, Inc.

引用

页码：1336 / 1342

页数：7

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