Immunohistochemical investigations on the course of astroglial GFAP expression following human brain injury

被引：89

作者：

Hausmann, R

Riess, R

Fieguth, A

Betz, P

机构：

[1] Univ Erlangen Nurnberg, Dept Legal Med, D-91054 Erlangen, Germany

[2] Klinikum Nurnberg Sud, Dept Pathol, D-90471 Nurnberg, Germany

[3] Hannover Med Sch, D-30625 Hannover, Germany

来源：

INTERNATIONAL JOURNAL OF LEGAL MEDICINE | 2000年 / 113卷 / 02期

关键词：

brain injury; cortical contusion; GFAP expression; immunohistochemistry; wound age;

D O I：

10.1007/PL00007711

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

The course of GFAP expression by astrocytes has been immunohistochemically investigated during the first 30 weeks after human brain injury. Ln order to provide reliable data for a forensic wound age estimation, a quantitative morphometric analysis was performed considering the different topographic regions of the cortex as well as of the white matter Compared to the GFAP immunoreactivity in unaltered control tissue, significantly increased numbers of GFAP positive astroglial cells could be detected adjacent to the cortical contusion from 1 day up to 4 weeks after brain injury.

引用

页码：70 / 75

页数：6

共 20 条

[1]

Baldwin SA, 1996, GLIA, V16, P266

[2] ASTROGLIAL RESPONSE TO STABBING - IMMUNOFLUORESCENCE STUDIES WITH ANTIBODIES TO ASTROCYTE-SPECIFIC PROTEIN (GFA) IN MAMMALIAN AND SUB-MAMMALIAN VERTEBRATES [J].