Structural determinants of T-cell receptor bias in immunity

被引：285

作者：

Turner, Stephen J. ^{[1
]}

Doherty, Peter C.

McCluskey, James

Rossjohn, Jamie

机构：

[1] Univ Melbourne, Dept Microbiol & Immunol, Parkville, Vic 3010, Australia

[2] Monash Univ, Dept Biochem & Mol Biol, Prot Crystallog Unit, Clayton, Vic 3800, Australia

来源：

NATURE REVIEWS IMMUNOLOGY | 2006年 / 6卷 / 12期

基金：

澳大利亚研究理事会; 英国医学研究理事会;

关键词：

D O I：

10.1038/nri1977

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Antigen-specific T-cell responses induced by infection, transplantation, autoimmunity or hypersensitivity are characterized by cells expressing biased profiles of T-cell receptors (TCRs) that are selected from a diverse, naive repertoire. Here, we review the evidence for these TCR biases, focusing on crystallographic analysis of the structural constraints that determine the binding of a TCR to its ligand and the persistence of certain TCRs in an immune repertoire. We discuss the ways in which diversity in a selected TCR repertoire can contribute to protective immunity and the implications of this for vaccine design and immunotherapy.

引用

页码：883 / 894

页数：12

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