Juvenile myelomonocytic leukemia: A report from the 2nd International JMML Symposium

被引：116

作者：

Chan, Rebecca J. ^{[2
]}

Cooper, Todd ^{[3
]}

Kratz, Christian P. ^{[4
]}

Weiss, Brian ^{[5
]}

Loh, Mignon L. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Pediat, San Francisco, CA 94143 USA

[2] Indiana Univ, Sch Med, Dept Pediat, Herman B Wells Ctr Pediat Res, Indianapolis, IN 46202 USA

[3] Univ Alabama Birmingham, Dept Pediat, Div Pediat Hematol Oncol, Birmingham, AL USA

[4] Univ Freiburg, Dept Pediat & Adolescent Med, Freiburg, Germany

[5] Univ Cincinnati, Med Ctr, Div Pediat Hematol Oncol, Dept Pediat,Cincinnati Childrens Hosp,Coll Med, Cincinnati, OH 45267 USA

来源：

LEUKEMIA RESEARCH | 2009年 / 33卷 / 03期

基金：

美国国家卫生研究院;

关键词：

Juvenile myelomonocytic leukemia (JMML); RAS; PTPN11; NF1; Therapy; Diagnosis; STEM-CELL TRANSPLANTATION; GENOTYPE-PHENOTYPE CORRELATION; COLONY-STIMULATING FACTOR; MUTATIONS CAUSE NOONAN; OF-FUNCTION MUTATIONS; PTPN11; MUTATIONS; MYELOPROLIFERATIVE DISORDER; MYELODYSPLASTIC SYNDROMES; TYPE-1; NEUROFIBROMATOSIS; GERMLINE MUTATIONS;

D O I：

10.1016/j.leukres.2008.08.022

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Juvenile myelomonocytic leukemia (JMML) is an aggressive childhood myeloproliferative disorder characterized by the overproduction of myelomonocytic cells. JMML incidence approaches 1.2/million persons in the United States (Cancer Incidence and Survival Among Children and Adolescents: United States SEER Program 1975-1995). Although rare, JMML is innately informative as the molecular genetics of this disease implicates hyperactive Ras as an essential initiating event. Given that Ras is one of the most frequently mutated oncogenes in human cancer, findings from this disease are applicable to more genetically diverse and complex adult leukemias. The JMML Foundation (www.jmmlfoundation.org) was founded by parent advocates dedicated to finding a cure for this disease. They work to bring investigators together in a collaborative manner. This article summarizes key presentations from The Second International JMML Symposium, on 7-8 December 2007 in Atlanta, GA. A list of all participants is in Supplementary Table. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：355 / 362

页数：8

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