Major Clinical Response to a BRAF Inhibitor in a Patient With a BRAF L597R-Mutated Melanoma

被引：45

作者：

Bahadoran, Philippe ^{[1
,2
,3
]}

Allegra, Maryline ^{[1
,3
]}

Le Duff, Florence ^{[1
]}

Long-Mira, Elodie ^{[4
]}

Hofman, Paul ^{[4
]}

Giacchero, Damien ^{[1
,5
]}

Passeron, Thierry ^{[1
,5
]}

Lacour, Jean-Philippe ^{[1
,5
]}

Ballotti, Robert ^{[1
,3
]}

机构：

[1] CHU Nice, F-06202 Nice, France

[2] CHU Nice, Clin Res Ctr, F-06202 Nice, France

[3] CHU Nice, Inst Natl Sante & Rech Med, U 1065, Team 1, F-06202 Nice, France

[4] CHU Nice, Biobank, F-06202 Nice, France

[5] CHU Nice, Inst Natl Sante & Rech Med, U 1065, Team 12, F-06202 Nice, France

来源：

JOURNAL OF CLINICAL ONCOLOGY | 2013年 / 31卷 / 19期

关键词：

MUTATIONS; PATHWAY;

D O I：

10.1200/JCO.2012.46.1061

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

引用

收藏

页码：E324 / E326

页数：3

相关论文

共 5 条

[1]

The role of BRAF V600 mutation in melanoma [J].

Ascierto, Paolo A. ;

Kirkwood, John M. ;

Grob, Jean-Jacques ;

Simeone, Ester ;

Grimaldi, Antonio M. ;

Maio, Michele ;

Palmieri, Giuseppe ;

Testori, Alessandro ;

Marincola, Francesco M. ;

Mozzillo, Nicola .

JOURNAL OF TRANSLATIONAL MEDICINE, 2012, 10

[2]

BRAFL597 Mutations in Melanoma Are Associated with Sensitivity to MEK Inhibitors [J].

Dahlman, Kimberly Brown ;

Xia, Junfeng ;

Hutchinson, Katherine ;

Ng, Charles ;

Hucks, Donald ;

Jia, Peilin ;

Atefi, Mohammad ;

Su, Zengliu ;

Branch, Suzanne ;

Lyle, Pamela L. ;

Hicks, Donna J. ;

Bozon, Viviana ;

Glaspy, John A. ;

Rosen, Neal ;

Solit, David B. ;

Netterville, James L. ;

Vnencak-Jones, Cindy L. ;

Sosman, Jeffrey A. ;

Ribas, Antoni ;

Zhao, Zhongming ;

Pao, William .

CANCER DISCOVERY, 2012, 2 (09) :791-797

[3]

PLX4032, a selective BRAFV600E kinase inhibitor, activates the ERK pathway and enhances cell migration and proliferation of BRAFWT melanoma cells [J].

Halaban, Ruth ;

Zhang, Wengeng ;

Bacchiocchi, Antonella ;

Cheng, Elaine ;

Parisi, Fabio ;

Ariyan, Stephan ;

Krauthammer, Michael ;

McCusker, James P. ;

Kluger, Yuval ;

Sznol, Mario .

PIGMENT CELL & MELANOMA RESEARCH, 2010, 23 (02) :190-200

[4]

Analytical Performance of a Real-time PCR-based Assay for V600 Mutations in the BRAF Gene, Used as the Companion Diagnostic Test for the Novel BRAF Inhibitor Vemurafenib in Metastatic Melanoma [J].

Halait, Harkanwal ;

DeMartin, Kelli ;

Shah, Sweta ;

Soviero, Stephen ;

Langland, Rachel ;

Cheng, Suzanne ;

Hillman, Grantland ;

Wu, Lin ;

Lawrence, H. Jeffrey .

DIAGNOSTIC MOLECULAR PATHOLOGY, 2012, 21 (01) :1-8

[5]

Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF [J].

Wan, PTC ;

Garnett, MJ ;

Roe, SM ;

Lee, S ;

Niculescu-Duvaz, D ;

Good, VM ;

Jones, CM ;

Marshall, CJ ;

Springer, CJ ;

Barford, D ;

Marais, R .

CELL, 2004, 116 (06) :855-867