Modulation of immune response by B7 family molecules in tumor microenvironments

被引：30

作者：

Flies, Dallas B. ^{[1
]}

Chen, Lieping ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Grad Program Immunol, Baltimore, MD 21218 USA

来源：

IMMUNOLOGICAL INVESTIGATIONS | 2006年 / 35卷 / 3-4期

关键词：

B7; co-inhibitory; co-stimulatory; microenvironment; tumor;

D O I：

10.1080/08820130600755017

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

The importance of co-stimulatory and co-inhibitory molecules has been confirmed on a grand scale; with the identification of new B7 family molecules, possessing both immune activating and inhibiting functions, this family has exploded onto the scene of immune regulation. Nowhere, however, has the role of B7 family members been more apparent than in the fight against cancer. In this review, we will discuss recent data regarding the essential and complex role of B7 family members in regulating the immune response within tumor microenvironment.

引用

页码：395 / 418

页数：24

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