Prions, BSE and food

被引：28

作者：

Dormont, D ^{[1
]}

机构：

[1] CEA, Serv Neurovirol, Ctr Rech Serv Sante Armees, Ecole Prat Hautes Etud, F-92265 Fontenay Aux Roses, France

来源：

INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY | 2002年 / 78卷 / 1-2期

关键词：

prions; TSE; BSE; molecular markers; risk assessment; variant of Creutzfeldt-Jakob Disease (cCJD);

D O I：

10.1016/S0168-1605(02)00240-4

中图分类号：

TS2 [食品工业];

学科分类号：

0832 [食品科学与工程];

摘要：

Biochemical and biophysical properties of prions including possible inactivation methods are reviewed. Possible molecular markers of transmissible spongiform encephalopathy (TSE) and mechanisms behind infectivity and correlation with clinical symptoms are discussed. The risk of Bovine Spongiform Encephalopathy (BSE) for humans i.e. variant Creutzfeldt-Jakob Disease (cCJD) is addressed in detail. The consequences of the emergence of the new cCJD and the lack of information on the infectivity of cCJD at the clinical stage of the disease in relation to the need to reconsider the biological concepts currently used in microbiology. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

收藏

页码：181 / 189

页数：9

相关论文

共 65 条

[1]

MS-8209, A NEW AMPHOTERICIN-B DERIVATIVE, PROVIDES ENHANCED EFFICACY IN DELAYING HAMSTER SCRAPIE [J].

ADJOU, KT ;

DEMAIMAY, R ;

LASMEZAS, C ;

DESLYS, JP ;

SEMAN, M ;

DORMONT, D .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1995, 39 (12) :2810-2812

[2]

Differential effects of a new amphotericin B derivative, MS-8209, on mouse BSE and scrapie: Implications for the mechanism of action of polyene antibiotics [J].

Adjou, KT ;

Demaimay, R ;

Lasmezas, CI ;

Seman, M ;

Deslys, JP ;

Dormont, D .

RESEARCH IN VIROLOGY, 1996, 147 (04) :213-218

[3]

INCIDENCE OF CREUTZFELDT-JAKOB-DISEASE IN EUROPE IN 1993 [J].

ALPEROVITCH, A ;

BROWN, P ;

WEBER, T ;

POCCHIARI, M ;

HOFMAN, A ;

WILL, R .

LANCET, 1994, 343 (8902) :918-918

[4]

Early accumulation of PrPSc in gut-associated lymphoid and nervous tissues of susceptible sheep from a Romanov flock with natural scrapie [J].

Andréoletti, O ;

Berthon, P ;

Marc, D ;

Sarradin, P ;

Grosclaude, J ;

van Keulen, L ;

Schelcher, F ;

Elsen, JM ;

Lantier, F .

JOURNAL OF GENERAL VIROLOGY, 2000, 81 :3115-3126

[5]

EXPERIMENTAL TRANSMISSION OF BSE AND SCRAPIE TO THE COMMON MARMOSET [J].

BAKER, HF ;

RIDLEY, RM ;

WELLS, GAH .

VETERINARY RECORD, 1993, 132 (16) :403-406

[6]

BOLTON DC, 1988, CIBA F SYMP, V135, P164

[7]

Prions in skeletal muscle [J].

Bosque, PJ ;

Ryou, C ;

Telling, G ;

Peretz, D ;

Legname, G ;

DeArmond, SJ ;

Prusiner, SB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (06) :3812-3817

[8]

EPIDEMIOLOGY AND CONTROL OF BOVINE SPONGIFORM ENCEPHALOPATHY (BSE) [J].

BRADLEY, R ;

WILESMITH, JW .

BRITISH MEDICAL BULLETIN, 1993, 49 (04) :932-959

[9]

Normal host prion protein necessary for scrapie-induced neurotoxicity [J].

Brandner, S ;

Isenmann, S ;

Raeber, A ;

Fischer, M ;

Sailer, A ;

Kobayashi, Y ;

Marino, S ;

Weissmann, C ;

Aguzzi, A .

NATURE, 1996, 379 (6563) :339-343

[10]

CREUTZFELDT-JAKOB DISEASE OF LONG DURATION - CLINICOPATHOLOGICAL CHARACTERISTICS, TRANSMISSIBILITY, AND DIFFERENTIAL-DIAGNOSIS [J].

BROWN, P ;

RODGERSJOHNSON, P ;

CATHALA, F ;

GIBBS, CJ ;

GAJDUSEK, DC .

ANNALS OF NEUROLOGY, 1984, 16 (03) :295-304

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