Antagonists of protein-protein interactions

被引：220

作者：

Cochran, AG ^{[1
]}

机构：

[1] Genentech Inc, Dept Prot Engn, San Francisco, CA 94080 USA

来源：

CHEMISTRY & BIOLOGY | 2000年 / 7卷 / 04期

关键词：

D O I：

10.1016/S1074-5521(00)00106-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Protein-protein interactions are often attractive, but not straightforward, targets for disease therapy. Two strategies for identifying inhibitors of these interactions, peptide phage display and high-throughput screening, have recently shown new promise.

引用

页码：R85 / R94

页数：10

共 77 条

[1] Can we learn to distinguish between "drug-like" and "nondrug-like" molecules?
Ajay
Walters, WP
Murcko, MA
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1998, 41 (18) : 3314 - 3324
[2] The properties of known drugs .1. Molecular frameworks
Bemis, GW
Murcko, MA
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (15) : 2887 - 2893
[3] Properties of known drugs. 2. Side chains
Bemis, GW
Murcko, MA
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1999, 42 (25) : 5095 - 5099
[4] Emergent properties of networks of biological signaling pathways
Bhalla, US
Iyengar, R
[J]. SCIENCE, 1999, 283 (5400) : 381 - 387
[5] Minimizing a binding domain from protein A
Braisted, AC
Wells, JA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (12) : 5688 - 5692
[6] Buzko OV, 1999, NAT STRUCT BIOL, V6, P906
[7] Core structure of gp41 from the HIV envelope glycoprotein
Chan, DC
Fass, D
Berger, JM
Kim, PS
[J]. CELL, 1997, 89 (02) : 263 - 273
[8] Evidence that a prominent cavity in the coiled coil of HIV type 1 gp41 is an attractive drug target
Chan, DC
Chutkowski, CT
Kim, PS
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (26) : 15613 - 15617
[9] Brefeldin A: The advantage of being uncompetitive
Chardin, P
McCormick, F
[J]. CELL, 1999, 97 (02) : 153 - 155
[10] DESIGN AND SYNTHESIS OF A CD4 BETA-TURN MIMETIC THAT INHIBITS HUMAN-IMMUNODEFICIENCY-VIRUS ENVELOPE GLYCOPROTEIN GP120 BINDING AND INFECTION OF HUMAN-LYMPHOCYTES
CHEN, SX
CHRUSCIEL, RA
NAKANISHI, H
RAKTABUTR, A
JOHNSON, ME
SATO, A
WEINER, D
HOXIE, J
SARAGOVI, HU
GREENE, MI
KAHN, M
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (13) : 5872 - 5876

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