The role of epigenetics in aging and age-related diseases

被引：239

作者：

Calvanese, Vincenzo ^{[1
]}

Lara, Ester ^{[1
]}

Kahn, Arnold ^{[2
]}

Fraga, Mario F. ^{[1
,3
]}

机构：

[1] CNB CSIC, Dept Immunol & Oncol, Natl Biotechnol Ctr, E-28049 Madrid, Spain

[2] San Francisco & Buck Inst Age Res, San Francisco Coordinating Ctr, Calif Pacific Med Ctr, Novato, CA USA

[3] Univ Oviedo, Canc Epigenet Lab, IUOPA, Oviedo, Spain

来源：

AGEING RESEARCH REVIEWS | 2009年 / 8卷 / 04期

关键词：

Epigenetics; Aging; DNA methylation; Chromatin; Histone modification; H4; LYSINE-20; TRIMETHYLATION; RECEPTOR CPG ISLAND; DNA METHYLATION; GENE-EXPRESSION; HISTONE H4; PROMOTER METHYLATION; GERMLINE EPIMUTATION; MONOZYGOTIC TWIN; CANCER; SIRT1;

D O I：

10.1016/j.arr.2009.03.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The role of epigenetics in aging and age-related diseases is a key issue in molecular physiology and medicine because certain epigenetic factors are thought to mediate, at least in part, the relationship between the genome and the environment. An active role for epigenetics in aging must meet two prior conditions: there must be specific epigenetic changes during aging and they must be functionally associated with the aged phenotype. Assuming that specific epigenetic modifications can have a direct functional outcome in aging, it is also essential to establish whether they depend on genetic, environmental or stochastic factors, and if they can be transmitted from one generation to the next. Here we discuss current knowledge about these matters and future directions in the field. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：268 / 276

页数：9

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