Analysis of complex chromosomal rearrangements in adult patients with MDS and AML by multicolor FISH

被引：16

作者：

Babicka, Libuse ^{[1
]}

Ransdorfova, Sarka

Brezinova, Jana

Zemanova, Zuzana

Sindelarova, Lenka

Siskova, Magda

Maaloufova, Jacqueline

Cermak, Jaroslav

Michalova, Kyra

机构：

[1] Gen Fac Hosp, Ctr Oncocytogenet, Inst Clin Biochem & Lab Diagnost, Prague, Czech Republic

[2] Charles Univ Prague, Fac Med 1, Prague, Czech Republic

[3] Inst Hematol & Blood Transfus, CR-12820 Prague, Czech Republic

[4] Gen Fac Hosp, Dept Med 1, Prague, Czech Republic

来源：

LEUKEMIA RESEARCH | 2007年 / 31卷 / 01期

关键词：

MDS; AML; complex chromosomal aberrations; mFISH; mBAND;

D O I：

10.1016/j.leukres.2006.03.010

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We analyzed complex chromosomal aberrations in 37 adult patients with myclodysplastic syndrome (MDS) and acute myeloid leukemia (AML) using classical cytogenetic method, FISH with locus-specific probes, multicolor FISH (mFISH) and multicolor banding (mBAND). Unbalanced structural aberrations, leading to a gain or loss of chromosomal material, were frequently observed in bone marrow cells. In 30 patients (81.1%) loss or rearrangement of chromosome 5, 7 and/or I I was found. The most frequent numerical change was trisomy 8 as expected (detected in six patients-16.2%) and the most frequent breakpoints 5q 13, 5q33, 7q3 1, 10p12, 11q23, 12p13, 17p11 and 21q22 were determined. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：39 / 47

页数：9

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