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Total synthesis of the amaryllidaceae alkaloid (+)-plicamine using solid-supported reagents

被引：101
作者：
Baxendale, IR
Ley, SV
Nessi, M
Piutti, C
机构：
[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England
[2] Pharmacia SpA, Dept Chem, Discovery Res Oncol, I-20014 Nerviano, MI, Italy
来源：
TETRAHEDRON | 2002年 / 58卷 / 32期
基金：
英国工程与自然科学研究理事会;
关键词：
amaryllidaceae; quinone; alkylation; solid-supported reagents;
D O I：
10.1016/S0040-4020(02)00628-2
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
In this report we describe in full the total synthesis of the amaryllidaceae alkaloid (+)-plicamine 1 including a model compound study. In both cases the compounds were prepared using solid-supported reagents and scavengers in multi-step sequences of reactions to give materials which required no conventional purification but could be carried on to the next synthetic step. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：6285 / 6304
页数：20
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