Hypothalamo-Pituitary-Adrenocortical Axis, Glucocorticoids, and Neurologic Disease

被引：20

作者：

Doczy, Erica J. ^{[1
,3
]}

Seroogy, Kim ^{[2
]}

Harrison, Catherine R. ^{[3
]}

Herman, James P. ^{[1
]}

机构：

[1] Univ Cincinnati, Coll Med, Dept Psychiat, GRI E, Cincinnati, OH 45237 USA

[2] Univ Cincinnati, Coll Med, Dept Neurol, Cincinnati, OH 45237 USA

[3] USAF, Res Lab, Wright Patterson AFB, OH 45433 USA

来源：

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA | 2009年 / 29卷 / 02期

关键词：

Stress; Glucocorticoid; Hypothalamo-pituitary-adrenocortical axis; Neurologic disease; Cortisol; Neurotrama; CORTICOTROPIN-RELEASING-FACTOR; TRAUMATIC BRAIN-INJURY; PLASMA-CORTICOSTERONE RESPONSES; HIPPOCAMPAL CA3C NEURONS; STRESS-INDUCED ATROPHY; MESSENGER-RNA LEVELS; INDUCED CELL-DEATH; PARAVENTRICULAR NUCLEUS; ADRENAL AXIS; RAT-BRAIN;

D O I：

10.1016/j.iac.2009.02.003

中图分类号：

R392 [医学免疫学];

学科分类号：

100108 [医学免疫学];

摘要：

Neurologic diseases are often accompanied by significant life stress and consequent increases in stress hormone levels. Glucocorticoid stress hormones are known to have deleterious interactions with neurodegenerative processes, and are hypersecreted in neurologic disorders as well as in comorbid psychiatric conditions, such as depression. This article highlights the state of our knowledge on mechanisms controlling activation and inhibition of glucocorticoid secretion, outlines signaling mechanisms used by these hormones in neural tissue, and describes how endogenous glucocorticoids can mediate neuronal damage in various models of neurologic disease. The article highlights the importance of controlling stress and consequent stress hormone secretion in the context of neurologic disease states.

引用

页码：265 / +

页数：21

共 137 条

[1]

FEEDBACK AND FACILITATION IN THE ADRENOCORTICAL SYSTEM - UNMASKING FACILITATION BY PARTIAL INHIBITION OF THE GLUCOCORTICOID RESPONSE TO PRIOR STRESS [J].