Theoretical conformation of the closed and open states of the acetylcholine receptor channel

被引：17

作者：

Corry, B ^{[1
]}

机构：

[1] Univ Western Australia, Dept Chem, Crawley, WA 6009, Australia

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 2004年 / 1663卷 / 1-2期

关键词：

acetylcholine receptor; pore; ion channel; gating; brownian dynamic;

D O I：

10.1016/j.bbamem.2004.02.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We conduct a theoretical analysis to show the recently imaged structure of the acetylcholine receptor pore is in a non-conducting state. A hypothesised open state consistent with a lower resolution image is created and shown to have high conductance. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：2 / 5

页数：4

共 9 条

[1] Brownian dynamics study of an open-state KcsA potassium channel [J].

Allen, TW ;

Chung, SH .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2001, 1515 (02) :83-91

[2] Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors [J].

Brejc, K ;

van Dijk, WJ ;

Klaassen, RV ;

Schuurmans, M ;

van der Oost, J ;

Smit, AB ;

Sixma, TK .

NATURE, 2001, 411 (6835) :269-276

[3] Conducting-state properties of the KcsA potassium channel from molecular and Brownian dynamics simulations [J].

Chung, SH ;

Allen, TW ;

Kuyucak, S .

BIOPHYSICAL JOURNAL, 2002, 82 (02) :628-645

[4] Mechanisms of permeation and selectivity in calcium channels [J].

Corry, B ;

Allen, TW ;

Kuyucak, S ;

Chung, SH .

BIOPHYSICAL JOURNAL, 2001, 80 (01) :195-214

[5] MULTIPLE CONDUCTANCE STATES OF SINGLE ACETYLCHOLINE-RECEPTOR CHANNELS IN EMBRYONIC MUSCLE-CELLS [J].

HAMILL, OP ;

SAKMANN, B .

NATURE, 1981, 294 (5840) :462-464

[6] Brownian dynamics study of ion transport in the vestibule of membrane channels [J].

Li, SC ;

Hoyles, M ;

Kuyucak, S ;

Chung, SH .

BIOPHYSICAL JOURNAL, 1998, 74 (01) :37-47

[7] Structure and gating mechanism of the acetylcholine receptor pore [J].

Miyazawa, A ;

Fujiyoshi, Y ;

Unwin, N .

NATURE, 2003, 423 (6943) :949-955

[8] Tests of continuum theories as models of ion channels. I. Poisson-Boltzmann theory versus Brownian dynamics [J].

Moy, G ;

Corry, B ;

Kuyucak, S ;

Chung, SH .

BIOPHYSICAL JOURNAL, 2000, 78 (05) :2349-2363

[9] ACETYLCHOLINE-RECEPTOR CHANNEL IMAGED IN THE OPEN STATE [J].

UNWIN, N .

NATURE, 1995, 373 (6509) :37-43

← 1 →