Transcranial magnetic stimulation for the treatment of seizures

被引：186

作者：

Theodore, WH ^{[1
]}

Hunter, K ^{[1
]}

Chen, R ^{[1
]}

Vega-Bermudez, F ^{[1
]}

Boroojerdi, B ^{[1
]}

Reeves-Tyer, P ^{[1
]}

Werhahn, K ^{[1
]}

Kelley, KR ^{[1
]}

Cohen, L ^{[1
]}

机构：

[1] NINDS, Human Cort Physiol Sect, NIH, Bethesda, MD 20892 USA

来源：

NEUROLOGY | 2002年 / 59卷 / 04期

关键词：

D O I：

10.1212/WNL.59.4.560

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: To perform a controlled trial of transcranial magnetic stimulation (TMS). Methods: Twenty-four patients with localization-related epilepsy were randomized to blinded active or placebo stimulation. Weekly seizure frequency was compared for 8 weeks before and after 1 week of 1-Hz TMS for 15 minutes twice daily. Results: When the 8-week baseline and post-stimulation periods were compared, active patients had a mean seizure frequency reduction of 0.045 +/- 0.13 and sham-stimulated control subjects -0.004 +/- 0.20. Over 2 weeks, actively treated patients had a mean reduction in weekly seizure frequency of 0.16 +/- 0.18 and sham-stimulated control subjects 0.01 +/- 0.24. Neither difference was significant. Conclusion: The effect of TMS on seizure frequency was mild and short lived.

引用

页码：560 / 562

页数：3

共 23 条

[1] Decreased susceptibility to pentylenetetrazol-induced seizures after low-frequency transcranial magnetic stimulation in rats [J].

Akamatsu, N ;

Fueta, Y ;

Endo, Y ;

Matsunaga, K ;

Uozumi, T ;

Tsuji, S .

NEUROSCIENCE LETTERS, 2001, 310 (2-3) :153-156

[2]

Barbarosie M, 1997, J NEUROSCI, V17, P9308

[3]

Barker AT, 1999, EEG CL N SU, P3

[4] Reduction of human visual cortex excitability using 1-Hz transcranial magnetic stimulation [J].

Boroojerdi, B ;

Prager, A ;

Muellbacher, W ;

Cohen, LG .

NEUROLOGY, 2000, 54 (07) :1529-1531

[5] Depression of motor cortex excitability by low-frequency transcranial magnetic stimulation [J].

Chen, R ;

Classen, J ;

Gerloff, C ;

Celnik, P ;

Wassermann, EM ;

Hallett, M ;

Cohen, LG .

NEUROLOGY, 1997, 48 (05) :1398-1403

[6] CEREBELLAR STIMULATION FOR SEIZURE CONTROL - 17-YEAR STUDY [J].

DAVIS, R ;

EMMONDS, SE .

STEREOTACTIC AND FUNCTIONAL NEUROSURGERY, 1992, 58 (1-4) :200-208

[7] Altered seizure susceptibility after high-frequency transcranial magnetic stimulation in rats [J].

Ebert, U ;

Ziemann, U .

NEUROSCIENCE LETTERS, 1999, 273 (03) :155-158

[8] LOCALIZING THE SITE OF MAGNETIC BRAIN-STIMULATION IN HUMANS [J].

EPSTEIN, CM ;

SCHWARTZBERG, DG ;

DAVEY, KR ;

SUDDERTH, DB .

NEUROLOGY, 1990, 40 (04) :666-670

[9] PLACEBO-CONTROLLED PILOT-STUDY OF CENTROMEDIAN THALAMIC-STIMULATION IN TREATMENT OF INTRACTABLE SEIZURES [J].

FISHER, RS ;

UEMATSU, S ;

KRAUSS, GL ;

CYSYK, BJ ;

MCPHERSON, R ;

LESER, RP ;

GORDON, B ;

SCHWERDT, P ;

RISE, M .

EPILEPSIA, 1992, 33 (05) :841-851

[10] Chronic treatment with repetitive transcranial magnetic stimulation inhibits seizure induction by electroconvulsive shock in rats [J].

Fleischmann, A ;

Hirschmann, S ;

Dolberg, OT ;

Dannon, PN ;

Grunhaus, L .

BIOLOGICAL PSYCHIATRY, 1999, 45 (06) :759-763

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