Solubility of flurbiprofen in supercritical carbon dioxide

被引：89

作者：

Duarte, ARC

Coimbra, P

de Sousa, HC

Duarte, CMM

机构：

[1] Inst Biol Expt & Tecnol, P-2780 Oeiras, Portugal

[2] Univ Coimbra, Dept Engn Quim, FCT, P-3030290 Coimbra, Portugal

来源：

JOURNAL OF CHEMICAL AND ENGINEERING DATA | 2004年 / 49卷 / 03期

关键词：

D O I：

10.1021/je034099b

中图分类号：

O414.1 [热力学];

学科分类号：

摘要：

Equilibrium solubility of flurbiprofen, a nonsteroidal antiinflammatory agent, in supercritical carbon dioxide was measured by a static analytical method in the pressure range from (8.0 to 25.0) MPa, at temperatures of (303.0, 313.0, and 323.0) K. The cosolvent effect of ethanol in the solubility of the bioactive compound in supercritical carbon dioxide was investigated at 18 MPa and 313 K. The results obtained have a potential application in supercritical processes for this drug. Experimental solubility data were correlated with an empirical density-based Chrastil model.

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页码：449 / 452

页数：4

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