Pharmacokinetics and bioavailability of cinnamic acid after oral administration of ramulus cinnamomi in rats

被引：56

作者：

Chen, Yingrong ^{[1
]}

Ma, Yueming ^{[1
,2
]}

Ma, Wei ^{[1
]}

机构：

[1] Shanghai Univ Tradit Chinese Med, Pharmacokinet Lab, Shanghai 201203, Peoples R China

[2] Shanghai Univ Tradit Chinese Med, Ctr Tradit Chinese Med & Syst Biol, Shanghai 201203, Peoples R China

来源：

EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS | 2009年 / 34卷 / 01期

关键词：

Ramulus Cinnamomi; cinnamic acid; cinnamaldehyde; pharmacokinetics; bioavailability;

D O I：

10.1007/BF03191384

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The pharmacokinetics of cinnamic acid (CA) after oral administration of Decoction of Ramulus Cinnamomi (RC) 7.4 g/kg [containing CA 7.62x10(-5) mol/kg and cinnamaldehyde (CNMA) 1.77x 10(-5) mol/kg], was compared with that after oral administration of pure CA 7.62x10(-5) mol/kg in rats. Plasma concentrations of CA and hippuric acid (HA) were determined by HPLC. Pharmacokinetic parameters were calculated from the plasma concentration-time data. CA was quickly absorbed and then metabolized mainly into HA. The AUC((0-1)) and AUC((0-infinity)) of CA were higher in RC group than those in pure CA group and the bioavailability of CA from RC was higher than that from pure CA. After ig administration of 3.79x10(-4) mol/kg, CNMA was at least partially metabolized into CA in stomach and small intestine and almost completely metabolized into CA in liver before it is absorbed into blood in rats. The results showed that plasma CA in RC group might partly come from transformation of CNMA in RC.

引用

页码：51 / 56

页数：6

共 9 条

[1]

HOU JY, 2002, PHARM TRADITIONAL CH, P30

[2]

LI CH, 2003, J CHIN MAT MED, V28, P1056

[3]

LI WL, 2008, J CHIN MAT MED, V33, P1192

[4]

LU JY, 2002, CHIN TRADIT HERB DRU, V33, P681

[5] METABOLISM OF TRANS-CINNAMIC ACID IN THE RAT AND THE MOUSE AND ITS VARIATION WITH DOSE [J].

NUTLEY, BP ;

FARMER, P ;

CALDWELL, J .

FOOD AND CHEMICAL TOXICOLOGY, 1994, 32 (10) :877-886

[6]

[冯慧萍 Ping Huiping], 2004, [中国药科大学学报, Journal of China Pharmaceutical University], V35, P328

[7] TISSUE DISTRIBUTION AND EXCRETION OF C-14-LABELED CINNAMIC ALDEHYDE FOLLOWING SINGLE AND MULTIPLE ORAL-ADMINISTRATION IN MALE FISCHER-344 RATS [J].

SAPIENZA, PP ;

IKEDA, GJ ;

WARR, PI ;

PLUMMER, SI ;

DAILEY, RE ;

LIN, CS .

FOOD AND CHEMICAL TOXICOLOGY, 1993, 31 (04) :253-261

[8]

Yang Changming, 2001, CHINESE TRADITIONAL, V32, P616

[9] TOXICOKINETICS OF CINNAMALDEHYDE IN F344 RATS [J].

YUAN, JH ;

DIETER, MP ;

BUCHER, JR ;

JAMESON, CW .

FOOD AND CHEMICAL TOXICOLOGY, 1992, 30 (12) :997-1004

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