Fluorescence Enhancement by Au Nanostructures: Nanoshells and Nanorods

被引：518

作者：

Bardhan, Rizia ^{[1
,3
]}

Grady, Nathaniel K. ^{[2
,3
]}

Cole, Joseph R. ^{[2
,3
]}

Joshi, Amit ^{[4
]}

Halas, Naomi J. ^{[1
,2
,3
]}

机构：

[1] Rice Univ, Dept Chem, Houston, TX 77005 USA

[2] Rice Univ, Dept Elect & Comp Engn, Houston, TX 77005 USA

[3] Rice Univ, Lab Nanophoton, Houston, TX 77005 USA

[4] Baylor Coll Med, Dept Radiol, Houston, TX 77005 USA

来源：

ACS NANO | 2009年 / 3卷 / 03期

关键词：

fluorescence enhancement; IR800; gold nanoshells; gold nanorods; frequency domain lifetime decay; PLASMON RESPONSE; GOLD NANORODS; SURFACE; SIZE; NANOPARTICLES; GROWTH;

D O I：

10.1021/nn900001q

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Metallic nanoparticles influence the quantum yield and lifetime of adjacent fluorophores in a manner dependent on the properties of the nanostructure. Here we directly compare the fluorescence enhancement of the near-infrared fluorophore IR800 by All nanoshells (NSs) and Au nanorods (NRs), where human serum albumin (HSA) serves as a spacer layer between the nanoparticle and the fluorophore. Our measurements reveal that the quantum yield of IR800 is enhanced from similar to 7% as an isolated fluorophore to 86% in a NSs-HSA-IR800 complex and 74% in a NRs-HSA-IR800 complex. This dramatic increase in fluorescence shows tremendous potential for contrast enhancement in fluorescence-based bioimaging.

引用

页码：744 / 752

页数：9

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