Ageing - Mice and mitochondria

被引：22

作者：

Martin, GM ^{[1
]}

Loeb, LA ^{[1
]}

机构：

[1] Univ Washington, Dept Pathol, Seattle, WA 98195 USA

来源：

NATURE | 2004年 / 429卷 / 6990期

关键词：

D O I：

10.1038/429357a

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

It can be hard to work out whether particular events are a cause or a correlate of ageing — do mutations in mitochondrial DNA, for instance, speed up the process of growing old? Some clever studies suggest so.

引用

页码：357 / +

页数：2

共 17 条

[1] Mutations of ANT1, Twinkle, and POLG1 in sporadic progressive external ophthalmoplegia (PEO) [J].

Agostino, A ;

Valletta, L ;

Chinnery, PF ;

Ferrari, G ;

Carrara, F ;

Taylor, RW ;

Schaefer, AM ;

Turnbull, DM ;

Tiranti, V ;

Zeviani, M .

NEUROLOGY, 2003, 60 (08) :1354-1356

[2] Premature aging in mice deficient in DNA repair and transcription [J].

de Boer, J ;

Andressoo, JO ;

de Wit, J ;

Huijmans, J ;

Beems, RB ;

van Steeg, H ;

Weeda, G ;

van der Horst, GTJ ;

van Leeuwen, W ;

Themmen, APN ;

Meradji, M ;

Hoeijmakers, JHJ .

SCIENCE, 2002, 296 (5571) :1276-1279

[3] Remarkable infidelity of polymerase γA associated with mutations in POLG1 exonuclease domain [J].

Del Bo, R ;

Bordoni, A ;

Sciacco, M ;

Di Fonzo, A ;

Galbiati, S ;

Crimi, M ;

Bresolin, N ;

Comi, GP .

NEUROLOGY, 2003, 61 (07) :903-908

[4] The mitochondrial p55 accessory subunit of human DNA polymerase γ enhances DNA binding, promotes processive DNA synthesis, and confers N-ethylmaleimide resistance [J].

Lim, SE ;

Longley, MJ ;

Copeland, WC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (53) :38197-38203

[5]

Martin G M, 1978, Birth Defects Orig Artic Ser, V14, P5

[6] Multi-organ characterization of mitochondrial genomic rearrangements in ad libitum and caloric restricted mice shaw striking somatic mitochondrial DNA rearrangements with age [J].

Melov, S ;

Minerfeld, D ;

Esposito, L ;

Wallace, DC .

NUCLEIC ACIDS RESEARCH, 1997, 25 (05) :974-982

[7] A progeroid syndrome in mice is caused by defects in A-type lamins [J].

Mounkes, LC ;

Kozlov, S ;

Hernandez, L ;

Sullivan, T ;

Stewart, CL .

NATURE, 2003, 423 (6937) :298-301

[8] Klotho: a fundamental regulator of aging [J].

Nabeshima, Y .

AGEING RESEARCH REVIEWS, 2002, 1 (04) :627-638

[9] Clonally expanded mtDNA point mutations are abundant in individual cells of human tissues [J].

Nekhaeva, E ;

Bodyak, ND ;

Kraytsberg, Y ;

McGrath, SB ;

Van Orsouw, NJ ;

Pluzhnikov, A ;

Wei, JY ;

Vijg, J ;

Khrapko, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (08) :5521-5526

[10]

ORSINI F, 2004, J BIOL CHEM

← 1 2 →