Homocysteine thiolactone is a positive effector of σS levels in Escherichia coli

被引：14

作者：

Goodrich-Blair, H ^{[1
]}

Kolter, R

机构：

[1] Univ Wisconsin, Dept Bacteriol, Madison, WI 53706 USA

[2] Harvard Univ, Sch Med, Dept Microbiol & Mol Genet, Boston, MA 02115 USA

来源：

FEMS MICROBIOLOGY LETTERS | 2000年 / 185卷 / 02期

关键词：

stationary phase; folate stress; metabolic signal; sigma factor;

D O I：

10.1016/S0378-1097(00)00080-X

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

sigma(S) is a regulator of the stationary phase response in Escherichia coli. Multi-copy suppressors were sought in a strain with decreased levels of sigma(S) and one such suppressor was found to encode HsrA, a putative efflux pump. Multi-copy expression of hsrA was shown to lead to accumulation of homocysteine, which is predicted to cause an increase in homocysteine thiolactone (HCTL) levels. A direct correlation between HCTL levels and sigma(S) accumulation was observed both in mutants and during normal cell growth, leading to the hypothesis that HCTL is a physiologically relevant positive effector of sigma(S) levels in vivo. (C) 2000 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：117 / 121

页数：5

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