Quantitative mapping of transverse relaxivity (1/T2) in hepatic iron overload:: a single spin-echo imaging methodology

被引:51
作者
Clark, PR [1 ]
St Pierre, TG [1 ]
机构
[1] Univ Western Australia, Dept Phys, Nedlands, WA 6907, Australia
关键词
iron overload; 1/T-2; mapping; biopsy; liver;
D O I
10.1016/S0730-725X(00)00118-1
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Recent research into the non-invasive assessment of hepatic iron concentrations using magnetic resonance imaging has shown that the proton transverse relaxivity (1/T-2) varies linearly with liver iron concentration. However, the development of an image-based system for the assessment of hepatic iron distribution has been confounded by the presence of motion induced artifacts in the T-2-weighted images. We report on the development of a single spin-echo imaging methodology that enables the generation of transverse relaxivity maps over the liver. A simple smoothing technique is used to accommodate the image intensity perturbations caused by abdominal motion. The relaxivity maps are consistent with the variation of iron concentration throughout the Liver. A Parzen density estimate and histogram of the relaxivity distribution are generated to assist in the visual assessment of the degree and variability of T-2 shortening with liver iron loading. It was found that one or two Gaussian functions could be used to characterize the relaxivity distributions with a small number of parameters. We propose that this methodology may be used in the clinical setting to monitor hepatic iron concentrations in the advent of an accurate transverse relaxivity calibration curve. (C) 2000 Elsevier Science Inc. All rights reserved.
引用
收藏
页码:431 / 438
页数:8
相关论文
共 43 条
[1]   UNEVEN HEPATIC IRON AND PHOSPHORUS DISTRIBUTION IN BETA-THALASSEMIA [J].
AMBU, R ;
CRISPONI, G ;
SCIOT, R ;
VANEYKEN, P ;
PARODO, G ;
IANNELLI, S ;
MARONGIU, F ;
SILVAGNI, R ;
NURCHI, V ;
COSTA, V ;
FAA, G ;
DESMET, VJ .
JOURNAL OF HEPATOLOGY, 1995, 23 (05) :544-549
[2]  
BLOEMBERGEN N, 1948, PHYS REV, V73, P678
[3]   MAGNETIC-RESONANCE IMAGING OF TRANSFUSIONAL HEMOSIDEROSIS COMPLICATING THALASSEMIA MAJOR [J].
BRASCH, RC ;
WESBEY, GE ;
GOODING, CA ;
KOERPER, MA .
RADIOLOGY, 1984, 150 (03) :767-771
[4]  
BROWN D W, 1985, Magnetic Resonance Imaging, V3, P275, DOI 10.1016/0730-725X(85)90357-1
[5]  
DIXON RM, 1994, HEPATOLOGY, V19, P904, DOI 10.1002/hep.1840190416
[6]   NUCLEAR MAGNETIC-RESONANCE IMAGING OF THE LIVER - INITIAL EXPERIENCE [J].
DOYLE, FH ;
PENNOCK, JM ;
BANKS, LM ;
MCDONNELL, MJ ;
BYDDER, GM ;
STEINER, RE ;
YOUNG, IR ;
CLARKE, GJ ;
PASMORE, T ;
GILDERDALE, DJ .
AMERICAN JOURNAL OF ROENTGENOLOGY, 1982, 138 (02) :193-200
[7]   LIVER IRON QUANTIFICATION - STUDIES IN AQUEOUS IRON SOLUTIONS, IRON-OVERLOADED RATS, AND PATIENTS WITH HEREDITARY HEMOCHROMATOSIS [J].
ENGELHARDT, R ;
LANGKOWSKI, JH ;
FISCHER, R ;
NIELSEN, P ;
KOOIJMAN, H ;
HEINRICH, HC ;
BUCHELER, E .
MAGNETIC RESONANCE IMAGING, 1994, 12 (07) :999-1007
[8]   T1 MAPPING FROM SPIN-ECHO AND STIMULATED ECHOES [J].
FRANCONI, F ;
SEGUIN, F ;
SONIER, CB ;
LEPAPE, A ;
AKOKA, S .
MEDICAL PHYSICS, 1995, 22 (11) :1763-1769
[9]   TRANSVERSE RELAXATION OF SOLVENT PROTONS INDUCED BY MAGNETIZED SPHERES - APPLICATION TO FERRITIN, ERYTHROCYTES, AND MAGNETITE [J].
GILLIS, P ;
KOENIG, SH .
MAGNETIC RESONANCE IN MEDICINE, 1987, 5 (04) :323-345
[10]   DECREASE OF QUANTAL SIZE AND QUANTAL CONTENT DURING TETANIC STIMULATION DETECTED BY FOCAL RECORDING [J].
GLAVINOVIC, MI .
NEUROSCIENCE, 1995, 69 (01) :271-281