Chlamydia pneumoniae seropositivity and cardiovascular risk factors:: The InCHIANTI study

被引:14
作者
Blanc, P
Corsi, AM
Gabbuti, A
Peduzzi, C
Meacci, F
Olivieri, F
Lauretani, F
Francesco, M
Ferrucci, L
机构
[1] Hosp SS Annunziata, Infect Dis Sect, Florence, Italy
[2] INRCA, Dept Geriatr, Lab Clin Epidemiol, Florence, Italy
[3] INRCA, Lab Mol Biol & Genet, Ancona, Italy
[4] NIA, Longitudinal Studies Sect, Clin Res Branch, Baltimore, MD 21224 USA
关键词
Chlamydia pneumoniae; elderly; inflammation; cytokines;
D O I
10.1111/j.1532-5415.2004.52453.x
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Objectives: To assess the prevalence of Chlamydia pneumoniae (CP) seropositivity and test the hypothesis that CP infection (CPI) is associated with cardiovascular (CV) risk factors and levels of inflammatory biomarkers. Design: Cross-sectional survey. Setting: Representative sample of the residents of Greve in Chianti and Bagno a Ripoli, two small towns located in the Chianti geographic area (Tuscany, Italy). Participants: A total of 1,304 (age-range: 20-103, 79% agedgreater than or equal to65) participants of the InCHIANTI study. Measurements: CP seropositivity was assessed using immunofluorescence. Previous CPI was defined as immunoglobulin (Ig) G greater than or equal to1/16 and <1/256, and recent CPI was defined as IgG greater than or equal to1/512 or IgM greater than or equal to1/16. Inflammatory markers included interleukin (IL)-6, soluble IL-6 receptor (sIL-6r), tumor necrosis factor-alpha (TNF-alpha), IL-1beta, IL-1 receptor antagonist (IL-1ra), iron, ferritin, and C-reactive protein (CRP). CV risk factors included smoking, body mass index (BMI), lipid profile, and hypertension. Results: The prevalence of CP seropositivity was 75%, increased with age, and was higher in men than in women (P<.01). CPI was not associated with IL-1beta, IL-1ra, iron, ferritin, CRP, BMI, lipids, and smoking. After adjusting for age and sex, previous or recent CPI was associated with higher TNF-alpha (P<.01), IL-6 (P<.03), sIL-6R (P<.01), and hypertension (P<.02). In additional age and sex-adjusted models, the associations between CPI and TNF-alpha, IL-6, sIL-6r, and hypertension appeared to be mutually independent. Conclusion: CP seropositivity is highly prevalent in the older population and is a significant, independent correlate of hypertension and circulating levels of TNF-alpha, IL-6, and sIL-6r.
引用
收藏
页码:1626 / 1631
页数:6
相关论文
共 50 条
  • [1] Chlamydia pneumoniae, but not Bartonella quintana, is associated with coronary heart disease:: results of a French case-control study
    Badiaga, S
    Paganelli, F
    Parola, P
    Beghin, M
    Barrau, K
    Eb, F
    Brouqui, P
    [J]. CLINICAL MICROBIOLOGY AND INFECTION, 2003, 9 (04) : 315 - 318
  • [2] Chlamydia pneumoniae and atherosclerosis:: Critical assessment of diagnostic methods and relevance to treatment studies
    Boman, J
    Hammerschlag, MR
    [J]. CLINICAL MICROBIOLOGY REVIEWS, 2002, 15 (01) : 1 - +
  • [3] Prevalence of specific antibodies to Chlamydia pneumoniae in Korea
    Choi, TY
    Kim, DA
    Kim, SK
    Kang, JO
    Park, SS
    Jung, SR
    [J]. JOURNAL OF CLINICAL MICROBIOLOGY, 1998, 36 (11) : 3426 - 3428
  • [4] CHUMLEA W, 1984, NUTR ASSESSMENT ELDE
  • [5] Chlamydia pneumoniae antibody titers are significantly associated with acute stroke and transient cerebral ischemia - The West Birmingham Stroke Project
    Cook, PJ
    Honeybourne, D
    Lip, GYH
    Beevers, DG
    Wise, R
    Davies, P
    [J]. STROKE, 1998, 29 (02) : 404 - 410
  • [6] Chlamydia pneumoniae antibodies in severe essential hypertension
    Cook, PJ
    Lip, GYH
    Davies, P
    Beevers, DG
    Wise, R
    Honeybourne, D
    [J]. HYPERTENSION, 1998, 31 (02) : 589 - 594
  • [7] Serum iron level, coronary artery disease, and all-cause mortality in older men and women
    Corti, MC
    Guralnik, JM
    Salive, ME
    Ferrucci, L
    Pahor, M
    Wallace, RB
    Hennekens, CH
    [J]. AMERICAN JOURNAL OF CARDIOLOGY, 1997, 79 (02) : 120 - 127
  • [8] Chronic infections and coronary heart disease: is there a link?
    Danesh, J
    Collins, R
    Peto, R
    [J]. LANCET, 1997, 350 (9075) : 430 - 436
  • [9] Association between past infection with Chlamydia pneumoniae and body mass index, low-density lipoprotein particle size and fasting insulin
    Dart, AM
    Martin, JL
    Kay, S
    [J]. INTERNATIONAL JOURNAL OF OBESITY, 2002, 26 (04) : 464 - 468
  • [10] DIXIT VM, 1990, J BIOL CHEM, V265, P2973