Neuronal traits are required for glucose-induced insulin secretion

被引：22

作者：

Abderrahmani, A

Niederhauser, G

Plaisance, V

Haefliger, JA

Regazzi, R

Waeber, G ^{[1
]}

机构：

[1] CHU Vaudois, Dept Internal Med, CH-1011 Lausanne, Switzerland

[2] Univ Lausanne, Inst Cell Biol & Morphol, Lausanne, Switzerland

来源：

FEBS LETTERS | 2004年 / 565卷 / 1-3期

关键词：

transcriptional repressor protein; insulin secretion; neuronal expression; beta-cell;

D O I：

10.1016/S0014-5793(04)00397-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The transcriptional repressor REI silencer transcription factor (REST) is an important factor that restricts some neuronal traits to neurons. Since these traits are also present in pancreatic beta-cells, we evaluated their role by generating a model of insulin-secreting cells that express REST. The presence of REST led to a decrease in expression of its known target genes, whereas insulin expression and its cellular content were conserved. As a consequence of REST expression, the capacity to secrete insulin in response to mitochondrial fuels, a particularity of mature beta-cells, was impaired. These data provide evidence that REST target genes are required for an appropriate glucose-induced insulin secretion. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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收藏

页码：133 / 138

页数：6

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